SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Contingent negative variation: a biomarker of abnormal attention in functional movement disorders

Teodoro, T; Koreki, A; Meppelink, AM; Little, S; Nielsen, G; Macerollo, A; Ferreira, JJ; Pareés, I; Lang, A; Edwards, MJ (2020) Contingent negative variation: a biomarker of abnormal attention in functional movement disorders. Eur J Neurol, 27 (6). pp. 985-994. ISSN 1468-1331 https://doi.org/10.1111/ene.14189
SGUL Authors: Edwards, Mark John James Nielsen, Glenn

[img]
Preview
PDF Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview
[img]
Preview
PDF Accepted Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

Background and purpose Contingent negative variation (CNV) is a negative cortical wave that precedes a pre‐cued imperative stimulus requiring a quick motor response. It has been related to motor preparation and anticipatory attention. The aim was to ascertain whether the clinical improvement of functional movement disorders after physiotherapy would be associated with faster reaction times and modulation of CNV. Methods Motor performance and CNV were analysed during a pre‐cued choice reaction time task with varying cue validity. Twenty‐one patients with functional movement disorders and 13 healthy controls at baseline were compared. Patients then underwent physiotherapy. At follow‐up after physiotherapy, patients were categorized as clinically improved (responders) or not improved (non‐responders) and retested. Results At baseline, patients did not generate CNV, contrary to controls [mean amplitude (µV) at the end of preparation to move: patients −0.47 (95% CI −1.94, 1.00) versus controls −2.59 (95% CI −4.46, −0.72)]. Responders performed faster after physiotherapy [mean natural logarithm (ln) reaction time (RT) (ms): follow‐up 6.112 (95% CI 5.923, 6.301) versus baseline 6.206 (95% CI 6.019, 6.394), P = 0.010], contrary to non‐responders. Simultaneously, responders showed a recovery of CNV after physiotherapy [follow‐up −1.95 (95% CI −3.49, −0.41) versus baseline −0.19 (95% CI −1.73, 1.35), P < 0.001], contrary to non‐responders [follow‐up −0.32 (95% CI −1.79, 1.14) versus baseline −0.72 (95% CI −2.19, 0.75), P = 0.381]. Conclusions Clinical improvement of functional movement disorders after physiotherapy was associated with faster reaction times and normalization of CNV, which was absent at baseline. These findings suggest that CNV may constitute a useful neurophysiological biomarker related to abnormal attention in functional movement disorders.

Item Type: Article
Additional Information: © 2020 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: 1103 Clinical Sciences, 1109 Neurosciences, Neurology & Neurosurgery
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Eur J Neurol
ISSN: 1468-1331
Language: eng
Dates:
DateEvent
15 May 2020Published
14 April 2020Published Online
22 February 2020Accepted
Publisher License: Creative Commons: Attribution 3.0
Projects:
Project IDFunderFunder ID
MR/M02363X/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
PubMed ID: 32096289
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/111702
Publisher's version: https://doi.org/10.1111/ene.14189

Actions (login required)

Edit Item Edit Item