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Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.

Donnelly, JP; Chen, SC; Kauffman, CA; Steinbach, WJ; Baddley, JW; Verweij, PE; Clancy, CJ; Wingard, JR; Lockhart, SR; Groll, AH; et al. Donnelly, JP; Chen, SC; Kauffman, CA; Steinbach, WJ; Baddley, JW; Verweij, PE; Clancy, CJ; Wingard, JR; Lockhart, SR; Groll, AH; Sorrell, TC; Bassetti, M; Akan, H; Alexander, BD; Andes, D; Azoulay, E; Bialek, R; Bradsher, RW; Bretagne, S; Calandra, T; Caliendo, AM; Castagnola, E; Cruciani, M; Cuenca-Estrella, M; Decker, CF; Desai, SR; Fisher, B; Harrison, T; Heussel, CP; Jensen, HE; Kibbler, CC; Kontoyiannis, DP; Kullberg, B-J; Lagrou, K; Lamoth, F; Lehrnbecher, T; Loeffler, J; Lortholary, O; Maertens, J; Marchetti, O; Marr, KA; Masur, H; Meis, JF; Morrisey, CO; Nucci, M; Ostrosky-Zeichner, L; Pagano, L; Patterson, TF; Perfect, JR; Racil, Z; Roilides, E; Ruhnke, M; Prokop, CS; Shoham, S; Slavin, MA; Stevens, DA; Thompson, GR; Vazquez, JA; Viscoli, C; Walsh, TJ; Warris, A; Wheat, LJ; White, PL; Zaoutis, TE; Pappas, PG (2020) Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis, 71 (6). pp. 1367-1376. ISSN 1537-6591 https://doi.org/10.1093/cid/ciz1008
SGUL Authors: Harrison, Thomas Stephen

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Abstract

BACKGROUND: Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have been of immense value to researchers who conduct clinical trials of antifungals, assess diagnostic tests, and undertake epidemiologic studies. However, their utility has not extended beyond patients with cancer or recipients of stem cell or solid organ transplants. With newer diagnostic techniques available, it was clear that an update of these definitions was essential. METHODS: To achieve this, 10 working groups looked closely at imaging, laboratory diagnosis, and special populations at risk of IFD. A final version of the manuscript was agreed upon after the groups' findings were presented at a scientific symposium and after a 3-month period for public comment. There were several rounds of discussion before a final version of the manuscript was approved. RESULTS: There is no change in the classifications of "proven," "probable," and "possible" IFD, although the definition of "probable" has been expanded and the scope of the category "possible" has been diminished. The category of proven IFD can apply to any patient, regardless of whether the patient is immunocompromised. The probable and possible categories are proposed for immunocompromised patients only, except for endemic mycoses. CONCLUSIONS: These updated definitions of IFDs should prove applicable in clinical, diagnostic, and epidemiologic research of a broader range of patients at high-risk.

Item Type: Article
Additional Information: © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: consensus, definitions, diagnosis, invasive fungal diseases, research, 06 Biological Sciences, 11 Medical and Health Sciences, Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Clin Infect Dis
ISSN: 1537-6591
Language: eng
Dates:
DateEvent
15 September 2020Published
5 December 2019Published Online
8 October 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
PubMed ID: 31802125
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111689
Publisher's version: https://doi.org/10.1093/cid/ciz1008

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