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A single‐centre review of iatrogenic anaemia in adult intensive care

Holland, J; Peralta, MR; Moss, RL; Feane, K; Uprichard, J (2020) A single‐centre review of iatrogenic anaemia in adult intensive care. TRANSFUSION MEDICINE. ISSN 0958-7578
SGUL Authors: Uprichard, James

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Objectives (a) To quantify the volume of diagnostic blood loss (DBL) and evaluate its impact on intensive care unit (ICU) patients, (b) examine the correlation between severity of disease and DBL and (c) identify potentially vulnerable patient subgroups. Background Iatrogenic anaemia is an important problem amongst ICU patients, with significant daily DBL. Methods A single‐centre observational cohort study was conducted at St George's Hospital, London, cardiac and general ICU. Forty patients were included in the study. Variables measured were volume of blood collected and discarded on a daily basis, Acute Physiology and Chronic Health Evaluation (APACHE) II score, frequency of phlebotomy, haemoglobin concentration before and after admission to ICU, reason for admission and complications developed in ICU. Results Mean (SD) total volume drawn per patient per day over 4 days was 86.3 mL (19.58). Nearly 30% of the total blood taken was discarded. There was a strong positive correlation between patients admitted because of sepsis and volume of DBL (P < .01), APACHE II score and volume taken (P = .01), patients who developed respiratory failure requiring ventilation and volume taken (P < .01) and patients who had received a blood transfusion and volume taken (P < .01). Haemoglobin concentration on discharge was negatively associated with DBL volume (P < .01). Conclusion High volumes of blood were taken and discarded from the study population, possibly reflecting the fact that there are no guidelines for ICU staff in terms of the amount of blood that needs to be withdrawn in order to “prime” access lines.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Holland, J, Peralta, RM, Moss, RL, Feane, K, Uprichard, J. A single‐centre review of iatrogenic anaemia in adult intensive care. Transfusion Med. 2020; 1– 5, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Keywords: Cardiovascular System & Hematology, 1103 Clinical Sciences
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: TRANSFUSION MEDICINE
ISSN: 0958-7578
1 March 2020Published Online
13 February 2020Accepted
Publisher License: Publisher's own licence
Publisher's version:

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