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Analysis of historical negative control group data from the rat in vivo micronucleus assay

Lovell, DP; Fellows, M; Saul, J; Whitwell, J; Custer, L; Dertinger, S; Escobar, P; Fiedler, R; Hemmann, U; Kenny, J; et al. Lovell, DP; Fellows, M; Saul, J; Whitwell, J; Custer, L; Dertinger, S; Escobar, P; Fiedler, R; Hemmann, U; Kenny, J; Smith, R; van der Leede, BM; Zeller, A (2020) Analysis of historical negative control group data from the rat in vivo micronucleus assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 849. p. 503086. ISSN 1383-5718 https://doi.org/10.1016/j.mrgentox.2019.503086
SGUL Authors: Lovell, David

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Abstract

A database of micronuclei counts for historical negative control data from rat in vivo micronuclei tests performed in 10 different laboratories was established. Data were available from over 4000 negative control rats from 10 laboratories. The mean frequency of micronucleated cells (MN)/1000 cells ranged from 0.44 to 2.22, a 5-fold range. Overall there were no major sex or strain differences in frequency, although there were some small but statistically significant differences within laboratories. There was appreciable variability between experiments compared with variability within experiments in some laboratories. No specific factor was identified which could explain this variability although it was noted that many different vehicles were used in the experiments. It is hoped that these data will help laboratories beginning studies with the rat micronucleus assay and those involved in the assessment of micronucleus assay results.

Item Type: Article
Additional Information: © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: 1002 Environmental Biotechnology, 1115 Pharmacology and Pharmaceutical Sciences, Toxicology
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Mutation Research/Genetic Toxicology and Environmental Mutagenesis
ISSN: 1383-5718
Language: en
Dates:
DateEvent
January 2020Published
12 October 2019Published Online
24 August 2019Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
URI: http://openaccess.sgul.ac.uk/id/eprint/111648
Publisher's version: https://doi.org/10.1016/j.mrgentox.2019.503086

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