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Fetal hydrops – a review and a clinical approach to identifying the cause

Dempsey, E; Homfray, T; Simpson, JM; Jeffery, S; Mansour, S; Ostergaard, P (2020) Fetal hydrops – a review and a clinical approach to identifying the cause. Expert Opinion on Orphan Drugs, 8 (2-3). pp. 51-66. ISSN 2167-8707
SGUL Authors: Dempsey, Esther Alice

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Introduction: Fetal hydrops describes abnormal fluid accumulation in two or more extravascular fetal compartments. It is a poor prognostic sign in a fetus, and many will not survive to term. Fetal hydrops is a clinical sign rather than a diagnosis and has a multitude of different causes. Areas covered: This review focusses on non-immune fetal hydrops. We discuss in detail the most common aetiologies such as infection and chromosomal abnormalities and cover rarer presentations of congenital malformation and single-gene disorders. We present a decision tree for the investigation of affected pregnancies. Expert opinion: The current approach to the investigation of fetal hydrops largely revolves around identifying the abnormal pathophysiology via ultrasound imaging. We believe that as genomic testing of a pregnancy can be undertaken with increasing accuracy, speed, accessibility and at reduced cost, genetic testing will feature earlier in the future diagnostic pathway.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Opinion on Orphan Drugs on 24/01/2020, available online:
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Expert Opinion on Orphan Drugs
ISSN: 2167-8707
Language: en
13 February 2020Published
24 January 2020Published Online
20 January 2020Accepted
Publisher License: Publisher's own licence
Project IDFunderFunder ID
FS/18/78/33932British Heart Foundation
Publisher's version:

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