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The pathogenic role of coronary microvascular dysfunction in the setting of other cardiac or systemic conditions.

Konst, RE; Guzik, TJ; Kaski, J-C; Maas, AHEM; Elias-Smale, SE (2020) The pathogenic role of coronary microvascular dysfunction in the setting of other cardiac or systemic conditions. Cardiovasc Res, 116 (4). pp. 817-828. ISSN 1755-3245 https://doi.org/10.1093/cvr/cvaa009
SGUL Authors: Kaski, Juan Carlos

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Abstract

Coronary microvascular dysfunction (CMD) plays a pathogenic role in cardiac and systemic conditions other than microvascular angina. In this review we provide an overview of the pathogenic role of CMD in the setting of diabetes mellitus, obesity, hypertensive pregnancy disorders, chronic inflammatory and autoimmune rheumatic disorders, chronic kidney disease, hypertrophic cardiomyopathy, and aortic valve stenosis. In these various conditions, CMD results from different structural, functional and/or dynamic alterations in the coronary microcirculation associated with the primary disease process. CMD is often detectable very early in the course of the primary disease, before clinical symptoms or signs of myocardial ischaemia are present, and it portrays an increased risk for cardiovascular events.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Cardiovascular Research following peer review. The version of record Regina E Konst, Tomasz J Guzik, Juan-Carlos Kaski, Angela H E M Maas, Suzette E Elias-Smale, The pathogenic role of coronary microvascular dysfunction in the setting of other cardiac or systemic conditions, Cardiovascular Research, Volume 116, Issue 4, 15 March 2020, Pages 817–828 is available online at: https://doi.org/10.1093/cvr/cvaa009
Keywords: 1102 Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Cardiovasc Res
ISSN: 1755-3245
Language: eng
Dates:
DateEvent
15 March 2020Published
8 February 2020Published Online
9 January 2020Accepted
Publisher License: Publisher's own licence
PubMed ID: 31977015
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/111610
Publisher's version: https://doi.org/10.1093/cvr/cvaa009

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