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Outcome of fetal echogenic bowel: a systematic review and meta-analysis

D'Amico, A; Buca, D; Rizzo, G; Khalil, A; Silvi, C; Makatsariya, A; Nappi, L; Liberati, M; D'Antonio, F (2020) Outcome of fetal echogenic bowel: a systematic review and meta-analysis. Prenat Diagn. ISSN 1097-0223
SGUL Authors: Khalil, Asma

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The main aim of this systematic review was to explore the outcome of fetuses with isolated echogenic bowel (EB) on antenatal ultrasound. Inclusion criteria were singleton pregnancies with isolated EB no associated major structural anomalies at the time of diagnosis. The outcomes observed were: chromosomal anomalies, cystic fibrosis, associated structural anomalies detected only at follow-up scans and at birth, regression during pregnancy, congenital infections, intra-uterine (IUD), neonatal (NND) and perinatal (PND) death. Twenty-five studies (12971 fetuses) were included. Chromosomal anomalies occurred in 3.3% of the fetuses, mainly Trisomy 21 and aneuploidies involving the sex chromosomes. Cystic fibrosis occurred in 2.2%. Congenital infections affected 2.2%, mainly congenital CMV infection. The majority of fetuses with EB experienced regression or disappearance of the EB at follow-up scans. Associated anomalies were detected at a follow-up scan in 1.8%. Associated anomalies were detected at birth and missed at ultrasound in 2.1% of cases. IUD occurred in 3.2% of cases while the corresponding figures for NND and PND were 0.4% and 3.1%. Fetuses with EB are at increased risk of adverse perinatal outcome, highlighting the need for a thorough antenatal management and post-natal follow-up. Assessment during pregnancy and after birth should be performed in order to look for signs of fetal aneuploidy, congenital infections and associated structural anomalies. This article is protected by copyright. All rights reserved.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: D'Amico, A., Buca, D., Rizzo, G., Khalil, A., Silvi, C., Makatsariya, A., Nappi, L., Liberati, M. and D'Antonio, F. (2020), Outcome of fetal echogenic bowel: a systematic review and meta‐analysis. Prenatal Diagnosis. Accepted Author Manuscript, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Keywords: Obstetrics & Reproductive Medicine, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Prenat Diagn
ISSN: 1097-0223
Language: eng
25 January 2020Published Online
8 December 2019Accepted
Publisher License: Publisher's own licence
PubMed ID: 31981377
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