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The DNA polymerases of Drosophila melanogaster.

Marygold, SJ; Attrill, H; Speretta, E; Warner, K; Magrane, M; Berloco, M; Cotterill, S; McVey, M; Rong, Y; Yamaguchi, M (2020) The DNA polymerases of Drosophila melanogaster. Fly (Austin). pp. 1-13. ISSN 1933-6942 https://doi.org/10.1080/19336934.2019.1710076
SGUL Authors: Cotterill, Susan Margaret

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Abstract

DNA synthesis during replication or repair is a fundamental cellular process that is catalyzed by a set of evolutionary conserved polymerases. Despite a large body of research, the DNA polymerases of Drosophila melanogaster have not yet been systematically reviewed, leading to inconsistencies in their nomenclature, shortcomings in their functional (Gene Ontology, GO) annotations and an under-appreciation of the extent of their characterization. Here, we describe the complete set of DNA polymerases in D. melanogaster, applying nomenclature already in widespread use in other species, and improving their functional annotation. A total of 19 genes encode the proteins comprising three replicative polymerases (alpha-primase, delta, epsilon), five translesion/repair polymerases (zeta, eta, iota, Rev1, theta) and the mitochondrial polymerase (gamma). We also provide an overview of the biochemical and genetic characterization of these factors in D. melanogaster. This work, together with the incorporation of the improved nomenclature and GO annotation into key biological databases, including FlyBase and UniProtKB, will greatly facilitate access to information about these important proteins.

Item Type: Article
Additional Information: © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: DNA polymerase, DNA replication, DNA synthesis, Drosophila melanogaster, translesion synthesis, 0602 Ecology, 0603 Evolutionary Biology, 0604 Genetics, Developmental Biology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Fly (Austin)
ISSN: 1933-6942
Language: eng
Dates:
DateEvent
14 January 2020Published
23 December 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
U41HG000739National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
MR/N030117/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
U24HG007822National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
PubMed ID: 31933406
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/111587
Publisher's version: https://doi.org/10.1080/19336934.2019.1710076

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