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Prenatal imaging features and postnatal outcomes of isolated fetal duplex renal collecting system: a systematic review and meta-analysis.

Bascietto, F; Khalil, A; Rizzo, G; Makatsariya, A; Buca, D; Silvi, C; Ucci, M; Liberati, M; Familiari, A; D'Antonio, F (2020) Prenatal imaging features and postnatal outcomes of isolated fetal duplex renal collecting system: a systematic review and meta-analysis. Prenat Diagn, 40 (4). pp. 424-431. ISSN 1097-0223 https://doi.org/10.1002/pd.5622
SGUL Authors: Khalil, Asma

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Abstract

OBJECTIVES: To perform a systematic review of studies reporting the outcome of fetuses with a prenatal diagnosis of isolated duplex collecting system (DCS). METHODS: Inclusion criteria were studies reporting the outcome of fetuses with a prenatal diagnosis of isolated DCS, defined as DCS not associated with other major structural anomalies at the time of diagnosis. The outcomes observed were: imaging features of DCS on prenatal ultrasound, associated anomalies detected exclusively at prenatal follow-up ultrasound and at birth, abnormal karyotype, symptoms at birth [including vesicoureteral reflux (VUR), urinary tract infections (UTI)], need for and type of surgical approach, complications after surgery and accuracy of prenatal ultrasound in correctly identifying this anomaly. RESULTS: Eleven studies (284 fetuses with a prenatal diagnosis of DCS) were included. On ultrasound, DCS was associated with ureterocele in 70.7% and with megaureter in 36.6% of cases. Worsening of pelvic/ureteric dilatation was reported to occur in 41.3% of fetuses. At birth, 4.3% of fetuses affected by DCS showed associated renal anomalies. After birth, VUR and UTI presented in 51.3% and 21.7% of children respectively, while 33.6% required surgery. Prenatal diagnosis of DCS was confirmed in 90.9% of included cases. CONCLUSION: DCS diagnosed prenatally is associated with a generally good outcome. Prenatal ultrasound has a good diagnostic accuracy, while detailed post-natal assessment is required in order to identify associated renal anomalies. This article is protected by copyright. All rights reserved.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Bascietto, F, Khalil, A, Rizzo, G, et al. Prenatal imaging features and postnatal outcomes of isolated fetal duplex renal collecting system: A systematic review and meta‐analysis. Prenatal Diagnosis. 2020; 40: 424– 431., which has been published in final form at https://doi.org/10.1002/pd.5622. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Keywords: Obstetrics & Reproductive Medicine, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Prenat Diagn
ISSN: 1097-0223
Language: eng
Dates:
DateEvent
30 March 2020Published
28 January 2020Published Online
7 November 2019Accepted
Publisher License: Publisher's own licence
PubMed ID: 31834636
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/111530
Publisher's version: https://doi.org/10.1002/pd.5622

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