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UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings

McFall, A; Hietamies, TM; Bernard, A; Aimable, M; Allan, SM; Bath, PM; Brezzo, G; Carare, RO; Carswell, HV; Clarkson, AN; et al. McFall, A; Hietamies, TM; Bernard, A; Aimable, M; Allan, SM; Bath, PM; Brezzo, G; Carare, RO; Carswell, HV; Clarkson, AN; Currie, G; Farr, TD; Fowler, JH; Good, M; Hainsworth, AH; Hall, C; Horsburgh, K; Kalaria, R; Kehoe, P; Lawrence, C; Macleod, M; McNeilly, A; Miller, AA; Miners, S; Mok, V; O'Sullivan, M; Platt, B; Sena, ES; Sharp, M; Strangeward, P; Szymkowiak, S; Touyz, RM; Trueman, RC; White, C; McCabe, C; Work, LM; Quinn, TJ (2020) UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. ISSN 0271-678X https://doi.org/10.1177/0271678X20910552
SGUL Authors: Hainsworth, Atticus Henry

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Abstract

Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying variability and what could be implemented to overcome identified challenges. Twelve UK VCI research centres were identified and invited to complete a questionnaire and attend a one-day workshop. Questionnaire responses demonstrated agreement that outcome assessments in VCI preclinical research vary by group and even those common across groups, may be performed differently. From the workshop, six themes were discussed: issues with preclinical models, reasons for choosing functional assessments, issues in interpretation of functional assessments, describing and reporting functional outcome assessments, sharing resources and expertise, and standardization of outcomes. Eight consensus points emerged demonstrating broadly that the chosen assessment should reflect the deficit being measured, and therefore that one assessment does not suit all models; guidance/standardisation on recording VCI outcome reporting is needed and that uniformity would be aided by a platform to share expertise, material, protocols and procedures thus reducing heterogeneity and so increasing potential for collaboration, comparison and replication. As a result of the workshop, UK wide consensus statements were agreed and future priorities for preclinical research identified.

Item Type: Article
Additional Information: This article has been accepted for publication in Journal of Cerebral Blood Flow and Metabolism.
Keywords: Neurology & Neurosurgery, 1103 Clinical Sciences, 1109 Neurosciences, 1102 Cardiorespiratory Medicine and Haematology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
ISSN: 0271-678X
Dates:
DateEvent
9 March 2020Published Online
6 December 2019Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
UNSPECIFIEDAlzheimer’s Research UKhttp://dx.doi.org/10.13039/501100002283
FS/15/64/32035British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
CU15007.0001Cunningham TrustUNSPECIFIED
URI: http://openaccess.sgul.ac.uk/id/eprint/111473
Publisher's version: https://doi.org/10.1177/0271678X20910552

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