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Idiopathic Myocardial Fibrosis in Captive Chimpanzees (Pan troglodytes).

Strong, V; Moittié, S; Sheppard, MN; Liptovszky, M; White, K; Redrobe, S; Cobb, M; Baiker, K (2020) Idiopathic Myocardial Fibrosis in Captive Chimpanzees (Pan troglodytes). Vet Pathol, 57 (1). pp. 183-191. ISSN 1544-2217 https://doi.org/10.1177/0300985819879442
SGUL Authors: Sheppard, Mary Noelle

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Abstract

Cardiovascular disorders and predominantly idiopathic myocardial fibrosis are frequently associated with mortality among zoo-housed chimpanzees (Pan troglodytes). Formalin-fixed whole hearts of deceased chimpanzees housed in zoos (n = 33) and an African sanctuary (n = 2) underwent detailed macroscopic and histopathologic examination using a standardized protocol. Archived histological slides from the hearts of 23 additional African sanctuary-housed chimpanzees were also examined. Myocardial fibrosis (MF) was identified in 30 of 33 (91%) of the zoo-housed chimpanzees but none of the 25 sanctuary-housed chimpanzees. MF was shown to be characterized by both interstitial and replacement fibrosis. Immunophenotyping demonstrated that the fibrotic lesions were accompanied by the increased presence of macrophages, alpha smooth muscle actin-positive myofibroblasts, and a minimal to mild T-cell-dominant leukocyte infiltration. There was no convincing evidence of cardiotropic viral infection or suggestion that diabetes mellitus or vitamin E or selenium deficiency were associated with the presence of the lesion. However, serum vitamin D concentrations among zoo-housed chimpanzees were found to be lower in seasons of low ultraviolet light levels.

Item Type: Article
Additional Information: Strong, V; Moittié, S; Sheppard, MN; Liptovszky, M; White, K; Redrobe, S; Cobb, M; Baiker, K, Idiopathic Myocardial Fibrosis in Captive Chimpanzees (Pan troglodytes), Veterinary Pathology (Vol 57 Issue 1) pp.183-191. Copyright © 2019 (SAGE Publications). DOI: 10.1177/0300985819879442.
Keywords: cardiac fibrosis, chimpanzee, diabetes mellitus, fibrosing cardiomyopathy, great ape, heart, interstitial myocardial fibrosis, vitamin D, cardiac fibrosis, fibrosing cardiomyopathy, chimpanzee, great ape, heart, interstitial myocardial fibrosis, diabetes mellitus, vitamin D, cardiac fibrosis, chimpanzee, diabetes mellitus, fibrosing cardiomyopathy, great ape, heart, interstitial myocardial fibrosis, vitamin D, 0704 Fisheries Sciences, 0707 Veterinary Sciences, Veterinary Sciences
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Vet Pathol
ISSN: 1544-2217
Language: eng
Dates:
DateEvent
1 January 2020Published
22 October 2019Published Online
Publisher License: Publisher's own licence
PubMed ID: 31640487
Web of Science ID: WOS:000491757500001
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/111412
Publisher's version: https://doi.org/10.1177/0300985819879442

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