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Granulysin: The attractive side of a natural born killer.

Sparrow, E; Bodman-Smith, MD (2020) Granulysin: The attractive side of a natural born killer. Immunol Lett, 217. pp. 126-132. ISSN 1879-0542 https://doi.org/10.1016/j.imlet.2019.11.005
SGUL Authors: Bodman-Smith, Mark Duncan

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Abstract

First discovered in the 1980's, granulysin has until recently been thought of solely as an effector molecule present within cytotoxic immune cell populations, and involved in the direct killing of pathogens and infected or transformed eukaryotic cells. However, recent research has suggested an additional role of granulysin, in particular the 15 kDa isoform. While 9 kDa granulysin is broadly cytotoxic and capable of the direct killing of bacteria and other pathogens, the 15 kDa isoform of this molecule has been shown to function as an immune 'alarmin', causing the maturation and migration of antigen-presenting cells and other cells of the immune system. This dual function of granulysin indirectly increases the immune response to an infection or tumour, and therefore escalates its importance in the immune system. Here we review the different roles of granulysin, both as a cytotoxic molecule, and as a modulator of the immune system, and discuss the impact this molecule may have on the response to tumour and infection.

Item Type: Article
Additional Information: © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Chemotaxis, Cytotoxicity, Granulysin, 1107 Immunology, Immunology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Immunol Lett
ISSN: 1879-0542
Language: eng
Dates:
DateEvent
January 2020Published
11 November 2019Published Online
10 November 2019Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 31726187
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/111399
Publisher's version: https://doi.org/10.1016/j.imlet.2019.11.005

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