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Group B streptococcal carriage, serotype distribution and antibiotic susceptibilities in pregnant women at the time of delivery in a refugee population on the Thai-Myanmar border.

Turner, C; Turner, P; Po, L; Maner, N; De Zoysa, A; Afshar, B; Efstratiou, A; Heath, PT; Nosten, F (2012) Group B streptococcal carriage, serotype distribution and antibiotic susceptibilities in pregnant women at the time of delivery in a refugee population on the Thai-Myanmar border. BMC Infect Dis, 12. p. 34. ISSN 1471-2334 https://doi.org/10.1186/1471-2334-12-34
SGUL Authors: Heath, Paul Trafford

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Abstract

BACKGROUND: Group B Streptococcus (GBS) is the leading cause of neonatal sepsis in the developed world. Little is known about its epidemiology in the developing world, where the majority of deaths from neonatal infections occur. Maternal carriage of GBS is a prerequisite for the development of early onset GBS neonatal sepsis but there is a paucity of carriage data published from the developing world, in particular South East Asia. METHODS: We undertook a cross sectional study over a 13 month period in a remote South East Asian setting on the Thai-Myanmar border. During labour, 549 mothers had a combined vaginal rectal swab taken for GBS culture. All swabs underwent both conventional culture as well as PCR for GBS detection. Cultured GBS isolates were serotyped by latex agglutination, those that were negative or had a weak positive reaction and those that were PCR positive but culture negative were additionally tested using multiplex PCR based on the detection of GBS capsular polysaccharide genes. RESULTS: The GBS carriage rate was 12.0% (95% CI: 9.4-15.0), with 8.6% positive by both culture and PCR and an additional 3.5% positive by PCR alone. Serotypes, Ia, Ib, II, III, IV, V, VI and VII were identified, with II the predominant serotype. All GBS isolates were susceptible to penicillin, ceftriaxone and vancomycin and 43/47 (91.5%) were susceptible to erythromycin and clindamycin. CONCLUSIONS: GBS carriage is not uncommon in pregnant women living on the Thai-Myanmar border with a large range of serotypes represented.

Item Type: Article
Additional Information: © 2012 Turner et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Anti-Bacterial Agents, Asia, Asia, Southeastern, Carrier State, Cross-Sectional Studies, Female, Humans, Infant, Newborn, Microbial Sensitivity Tests, Myanmar, Perineum, Pregnancy, Pregnancy Complications, Infectious, Prevalence, Rectum, Refugees, Serotyping, Streptococcal Infections, Streptococcus agalactiae, Thailand, Vagina, Perineum, Rectum, Vagina, Humans, Streptococcus agalactiae, Streptococcal Infections, Pregnancy Complications, Infectious, Anti-Bacterial Agents, Serotyping, Microbial Sensitivity Tests, Prevalence, Cross-Sectional Studies, Carrier State, Pregnancy, Infant, Newborn, Refugees, Asia, Asia, Southeastern, Myanmar, Thailand, Female, Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, INFECTIOUS DISEASES, NEONATAL SEPSIS, RAPID DETECTION, PCR ASSAYS, DISEASE, COLONIZATION, EPIDEMIOLOGY, PREVALENCE, CULTURE, INFANTS, MALAWI, 0605 Microbiology, 1103 Clinical Sciences, 1108 Medical Microbiology, Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: BMC Infect Dis
ISSN: 1471-2334
Language: eng
Dates:
DateEvent
8 February 2012Published
8 February 2012Accepted
Publisher License: Creative Commons: Attribution 2.0
Projects:
Project IDFunderFunder ID
089275Wellcome Trusthttp://dx.doi.org/10.13039/100004440
077166/Z/05Wellcome Trusthttp://dx.doi.org/10.13039/100004440
083735Wellcome Trusthttp://dx.doi.org/10.13039/100004440
SM10Li Ka Shing Foundationhttp://dx.doi.org/10.13039/100007421
PubMed ID: 22316399
Web of Science ID: WOS:000302462100001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111331
Publisher's version: https://doi.org/10.1186/1471-2334-12-34

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