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The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome.

Crosbie, EJ; Ryan, NAJ; Arends, MJ; Bosse, T; Burn, J; Cornes, JM; Crawford, R; Eccles, D; Frayling, IM; Ghaem-Maghami, S; et al. Crosbie, EJ; Ryan, NAJ; Arends, MJ; Bosse, T; Burn, J; Cornes, JM; Crawford, R; Eccles, D; Frayling, IM; Ghaem-Maghami, S; Hampel, H; Kauff, ND; Kitchener, HC; Kitson, SJ; Manchanda, R; McMahon, RFT; Monahan, KJ; Menon, U; Møller, P; Möslein, G; Rosenthal, A; Sasieni, P; Seif, MW; Singh, N; Skarrott, P; Snowsill, TM; Steele, R; Tischkowitz, M; Manchester International Consensus Group; Evans, DG (2019) The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome. Genet Med, 21 (10). pp. 2390-2400. ISSN 1530-0366 https://doi.org/10.1038/s41436-019-0489-y
SGUL Authors: Hodgson, Shirley Victoria

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Abstract

PURPOSE: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients. METHODS: Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice. RESULTS: Guidance was developed in four key areas: (1) whether women with gynecological cancer should be screened for Lynch syndrome and (2) how this should be done, (3) whether there was a role for gynecological surveillance in women at risk of Lynch syndrome, and (4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer. CONCLUSION: This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.

Item Type: Article
Additional Information: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2019
Keywords: Lynch syndrome, endometrial cancer, guidance, screening, surveillance, Manchester International Consensus Group, Lynch syndrome, endometrial cancer, screening, surveillance, guidance, 0604 Genetics, 1103 Clinical Sciences, Genetics & Heredity
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cell Sciences (INCCCS)
Journal or Publication Title: Genet Med
ISSN: 1530-0366
Language: eng
Dates:
DateEvent
October 2019Published
28 March 2019Published Online
6 March 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
NF-SI- 0513-10076National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
NIHR-CS-012-009National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
IS-BRC-1215-20007National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
MR/M018431/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
PubMed ID: 30918358
Web of Science ID: WOS:000488530100029
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111294
Publisher's version: https://doi.org/10.1038/s41436-019-0489-y

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