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Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification.

Michaud, K; Basso, C; d'Amati, G; Giordano, C; Kholová, I; Preston, SD; Rizzo, S; Sabatasso, S; Sheppard, MN; Vink, A; et al. Michaud, K; Basso, C; d'Amati, G; Giordano, C; Kholová, I; Preston, SD; Rizzo, S; Sabatasso, S; Sheppard, MN; Vink, A; van der Wal, AC; Association for European Cardiovascular Pathology (AECVP) (2020) Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification. Virchows Arch, 476 (2). pp. 179-194. ISSN 1432-2307 https://doi.org/10.1007/s00428-019-02662-1
SGUL Authors: Sheppard, Mary Noelle

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Abstract

Ischemic heart disease is one of the leading causes of morbidity and death worldwide. Consequently, myocardial infarctions are often encountered in clinical and forensic autopsies, and diagnosis can be challenging, especially in the absence of an acute coronary occlusion. Precise histopathological identification and timing of myocardial infarction in humans often remains uncertain while it can be of crucial importance, especially in a forensic setting when third person involvement or medical responsibilities are in question. A proper post-mortem diagnosis requires not only up-to-date knowledge of the ischemic coronary and myocardial pathology, but also a correct interpretation of such findings in relation to the clinical scenario of the deceased. For these reasons, it is important for pathologists to be familiar with the different clinically defined types of myocardial infarction and to discriminate myocardial infarction from other forms of myocardial injury. This article reviews present knowledge and post-mortem diagnostic methods, including post-mortem imaging, to reveal the different types of myocardial injury and the clinical-pathological correlations with currently defined types of myocardial infarction.

Item Type: Article
Additional Information: © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Acute coronary syndromes, Autopsy, Immunohistochemistry, Myocardial infarction, Myocardial injury, Post-mortem imaging, 1103 Clinical Sciences, Pathology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Virchows Arch
ISSN: 1432-2307
Language: eng
Dates:
DateEvent
February 2020Published
14 September 2019Published Online
28 August 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
PubMed ID: 31522288
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/111178
Publisher's version: https://doi.org/10.1007/s00428-019-02662-1

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