SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome

Milman, A; Andorin, A; Postema, PG; Gourraud, J-B; Sacher, F; Mabo, P; Kim, S-H; Maeda, S; Takahashi, Y; Kamakura, T; et al. Milman, A; Andorin, A; Postema, PG; Gourraud, J-B; Sacher, F; Mabo, P; Kim, S-H; Maeda, S; Takahashi, Y; Kamakura, T; Aiba, T; Conte, G; Juang, JJ; Leshem, E; Michowitz, Y; Fogelman, R; Hochstadt, A; Mizusawa, Y; Giustetto, C; Arbelo, E; Huang, Z; Corrado, D; Delise, P; Allocca, G; Takagi, M; Wijeyeratne, YD; Mazzanti, A; Brugada, R; Casado-Arroyo, R; Champagne, J; Calo, L; Sarquella-Brugada, G; Jespersen, CH; Tfelt-Hansen, J; Veltmann, C; Priori, SG; Behr, ER; Yan, G-X; Brugada, J; Gaita, F; Wilde, AAM; Brugada, P; Kusano, KF; Hirao, K; Nam, G-B; Probst, V; Belhassen, B (2019) Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome. Heart Rhythm, 16 (10). pp. 1468-1474. ISSN 1556-3871 https://doi.org/10.1016/j.hrthm.2019.07.003
SGUL Authors: Behr, Elijah Raphael

[img]
Preview
PDF Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (617kB) | Preview

Abstract

Background There is limited information on ethnic differences between patients with Brugada syndrome (BrS) and arrhythmic events (AEs). Objective The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between white and Asian patients with BrS and AEs. Methods The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter survey from Western and Asian countries, gathering 678 patients with BrS and first documented AE. After excluding patients with other (n = 14 [2.1%]) or unknown (n = 30 [4.4%]) ethnicity, 364 (53.7%) whites and 270 (39.8%) Asians comprised the study group. Results There was no difference in AE age onset (41.3 ± 16.1 years in whites vs 43.3 ± 12.3 years in Asians; P = .285). Higher proportions of whites were observed in pediatric and elderly populations. Asians were predominantly men (98.1% vs 85.7% in whites; P < .001) and frequently presented with aborted cardiac arrest (71.1% vs 56%; P < .001). Asians tended to display more spontaneous type 1 BrS-ECG pattern (71.5% vs 64.3%; P = .068). A family history of sudden cardiac death was noted more in whites (29.1% vs 11.5%; P < .001), with a higher rate of SCN5A mutation carriers (40.1% vs 13.2% in Asians; P < .001), as well as more fever-related AEs (8.5% vs 2.9%; P = .011). No difference was observed between the 2 groups regarding history of syncope and ventricular arrhythmia inducibility. Conclusion There are important differences between Asian and white patients with BrS. Asian patients present almost exclusively as male adults, more often with aborted cardiac arrest and spontaneous type 1 BrS-ECG. However, they have less family history of sudden cardiac death and markedly lower SCN5A mutation rates. The striking difference in SCN5A mutation rates should be tested in future studies.

Item Type: Article
Additional Information: © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Asian, Brugada Syndrome, SCN5A mutation, White, arrhythmic event, 1102 Cardiovascular Medicine And Haematology, 0903 Biomedical Engineering, Cardiovascular System & Hematology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Heart Rhythm
ISSN: 1556-3871
Language: eng
Dates:
DateEvent
October 2019Published
5 July 2019Published Online
3 July 2019Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 31284050
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111054
Publisher's version: https://doi.org/10.1016/j.hrthm.2019.07.003

Actions (login required)

Edit Item Edit Item