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Mycoplasma pneumoniae detection in children with respiratory tract infections and influence on management – a retrospective cohort study in Switzerland

Dierig, A; Hirsch, HH; Decker, M-L; Bielicki, JA; Heininger, U; Ritz, N (2020) Mycoplasma pneumoniae detection in children with respiratory tract infections and influence on management – a retrospective cohort study in Switzerland. Acta Paediatr, 109 (2). pp. 375-380. ISSN 1651-2227 https://doi.org/10.1111/apa.14891
SGUL Authors: Bielicki, Julia Anna

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Abstract

Aim To evaluate the frequency of Mycoplasma pneumoniae in nasopharyngeal specimens from children with respiratory tract infections (RTIs) and to detail clinical characteristics and management. Methods The study was designed as a retrospective cohort study. All children with RTI and nucleic acid amplification testing from nasopharyngeal specimens were analysed. Clinical data were extracted from electronic health records for all M. pneumoniae‐positive cases. Stored samples of cases and a random selection of matched controls were retested using a M. pneumoniae‐specific nucleic acid amplification test. Results Of 4460 children, 70 (1.6%) were positive for M. pneumoniae with a median age of 6.4 (IQR: 2.7–9.7). M. pneumoniae was the only organism identified in 50/64 (78%) cases. Macrolide treatment was prescribed in 52/65 (80%); prescription was empirical in 29/52 (56%) and targeted in 23/52 (44%) with no difference regarding patient age, oxygen requirement or duration of hospitalisation. Conclusion The prevalence of M. pneumoniae in nasopharyngeal specimens of children with RTI was low. The detection of M. pneumoniae influenced antibiotic prescriptions, but the benefit of early empirical versus targeted treatment remains unclear.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Dierig, A., Hirsch, H.H., Decker, M.‐L., Bielicki, J.A., Heininger, U. and Ritz, N. (2020), Mycoplasma pneumoniae detection in children with respiratory tract infections and influence on management – a retrospective cohort study in Switzerland. Acta Paediatr, 109: 375-380, which has been published in final form at https://doi.org/10.1111/apa.14891. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Keywords: LRTI, Pneumonia, bronchitis, macrolides, x-ray, 1114 Paediatrics And Reproductive Medicine, Pediatrics
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Acta Paediatr
ISSN: 1651-2227
Language: eng
Dates:
DateEvent
13 January 2020Published
27 June 2019Published Online
4 June 2019Accepted
Publisher License: Publisher's own licence
PubMed ID: 31168877
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/110932
Publisher's version: https://doi.org/10.1111/apa.14891

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