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Screening for Aphasia in NeuroDegeneration for the Diagnosis of Patients with Primary Progressive Aphasia: Clinical Validity and Psychometric Properties.

Battista, P; Catricalà, E; Piccininni, M; Copetti, M; Esposito, V; Polito, C; Miozzo, A; Gobbi, E; Cuoco, S; Boschi, V; et al. Battista, P; Catricalà, E; Piccininni, M; Copetti, M; Esposito, V; Polito, C; Miozzo, A; Gobbi, E; Cuoco, S; Boschi, V; Picillo, M; Sorbi, S; Barone, P; Iannaccone, S; Garrard, P; Logroscino, G; Cappa, SF (2018) Screening for Aphasia in NeuroDegeneration for the Diagnosis of Patients with Primary Progressive Aphasia: Clinical Validity and Psychometric Properties. Dement Geriatr Cogn Disord, 46 (3-4). pp. 243-252. ISSN 1421-9824 https://doi.org/10.1159/000492632
SGUL Authors: Garrard, Peter

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Abstract

BACKGROUND: We evaluated the psychometric proprieties of the Screening for Aphasia in NeuroDegeneration (SAND) battery in Italian primary progressive aphasia (PPA) and movement disorder (MD) patients. METHODS: The sample included 30 consecutive PPA and 45 MD patients who completed the SAND battery together with a clinical interview and a neurological/neuropsychological examination and 130 healthy controls (HC). RESULTS: The SAND battery showed good internal consistency and good convergent and divergent validity. receiver operating characteristic analysis revealed an area under the curve of 0.978 for PPA versus HC and of 0.786 for PPA versus MD. A cutoff ≥3 gave a sensitivity of 0.933% and a specificity of 0.946% for discriminating PPA versus HC, whereas a cutoff ≥5 gave a sensitivity of 0.767% and a specificity of 0.667% for discriminating PPA versus MD. CONCLUSION: These results indicate that the SAND battery is an adequate, reliable, and valid diagnostic tool for PPA.

Item Type: Article
Additional Information: This is the peer-reviewed but unedited manuscript version of the following article: Dement Geriatr Cogn Disord 2018;46:243–252 (DOI: 10.1159/000492632). The final, published version is available at http://www.karger.com/?doi=10.1159/000492632.
Keywords: Dementia, Diagnostic accuracy, Language impairment, Screening instrument, Speech-language assessment, Aged, Aphasia, Primary Progressive, Female, Humans, Italy, Male, Mass Screening, Middle Aged, Movement Disorders, Neurodegenerative Diseases, Neurologic Examination, Neuropsychological Tests, Psychometrics, ROC Curve, Reproducibility of Results, Speech Production Measurement, Humans, Aphasia, Primary Progressive, Movement Disorders, Neurodegenerative Diseases, Neurologic Examination, Mass Screening, Speech Production Measurement, Reproducibility of Results, ROC Curve, Neuropsychological Tests, Psychometrics, Aged, Middle Aged, Italy, Female, Male, Language impairment, Screening instrument, Dementia, Diagnostic accuracy, Speech-language assessment, Language impairment, Screening instrument, Dementia, Diagnostic accuracy, Speech-language assessment, 1103 Clinical Sciences, 1702 Cognitive Science, 1109 Neurosciences, Geriatrics
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Dement Geriatr Cogn Disord
ISSN: 1421-9824
Language: eng
Dates:
DateEvent
November 2018Published
23 October 2018Published Online
2 August 2018Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
G0801370Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/N025881/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
PubMed ID: 30352431
Web of Science ID: WOS:000450649800012
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110894
Publisher's version: https://doi.org/10.1159/000492632

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