Hanzlíková, Z;
Kofler, M;
Slovák, M;
Věchetová, G;
Fečíková, A;
Kemlink, D;
Sieger, T;
Růžička, E;
Valls-Solé, J;
Edwards, MJ;
et al.
Hanzlíková, Z; Kofler, M; Slovák, M; Věchetová, G; Fečíková, A; Kemlink, D; Sieger, T; Růžička, E; Valls-Solé, J; Edwards, MJ; Serranová, T
(2019)
Prepulse inhibition of the blink reflex is abnormal in functional movement disorders.
Mov Disord, 34 (7).
pp. 1022-1030.
ISSN 1531-8257
https://doi.org/10.1002/mds.27706
SGUL Authors: Edwards, Mark John James
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Abstract
BACKGROUND: Patients with functional movement disorders also typically have functional somatic symptoms, including pain, fatigue, and sensory disturbance. A potentially unifying mechanism for such symptoms is a failure in processing of sensory inputs. Prepulse inhibition is a neurophysiological method that allows for the study of preconscious somatosensory processing. OBJECTIVE: The objective of this study was to assess prepulse inhibition in patients with functional movement disorders and healthy control subjects. METHODS: We analyzed the effect of a weak electrical stimulus to the index finger (prepulse) on the magnitude of the R2 response of the blink reflex induced by electrical stimuli delivered to the supraorbital nerve in 22 patients with clinically established functional movement disorders and 22 matched controls. Pain, depression, anxiety, and obsessive-compulsive symptoms were assessed using self-rated questionnaires. In addition, in patients we assessed motor symptom severity. RESULTS: Prepulses suppressed the R2 response of the blink reflex in both groups, by 36.4% (standard deviation: 25.6) in patients and by 67.3% (standard deviation: 16.4) in controls. This difference was significant (P < 0.001). There was no significant correlation between motor and nonmotor symptom measures and prepulse inhibition size. CONCLUSIONS: Impaired prepulse inhibition of the blink reflex suggests an abnormal preconscious processing of somatosensory inputs, which can be interpreted within predictive coding accounts of both functional movement disorders and functional somatic syndromes. Our results, along with previous findings of a reduced prepulse inhibition in fibromyalgia syndrome, support a possible unified pathophysiology across functional neurological and somatic syndromes with noteworthy implications for diagnostic classification and development of novel biomarkers and treatments. © 2019 International Parkinson and Movement Disorder Society.
Item Type: |
Article
|
Additional Information: |
This is the peer reviewed version of the following article: Hanzlíková, Z. , Kofler, M. , Slovák, M. , Věchetová, G. , Fečíková, A. , Kemlink, D. , Sieger, T. , Růžička, E. , Valls‐Solé, J. , Edwards, M. J. and Serranová, T. (2019), Prepulse inhibition of the blink reflex is abnormal in functional movement disorders. Mov Disord, 34: 1022-1030, which has been published in final form at https://doi.org/10.1002/mds.27706. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: |
attention, blink reflex, functional movement disorders, prepulse inhibition, sensory integration, attention, blink reflex, functional movement disorders, prepulse inhibition, sensory integration, 1103 Clinical Sciences, 1106 Human Movement And Sports Science, 1702 Cognitive Science, Neurology & Neurosurgery |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) |
Journal or Publication Title: |
Mov Disord |
ISSN: |
1531-8257 |
Language: |
eng |
Dates: |
Date | Event |
---|
19 July 2019 | Published | 2 May 2019 | Published Online | 7 April 2019 | Accepted |
|
Publisher License: |
Publisher's own licence |
Projects: |
Project ID | Funder | Funder ID |
---|
16-29651 | Ministry of Health of the Czech Republic | UNSPECIFIED | CZ.02.1.01/0.0/16 - 019/0000765 | Research Centre for Informatics | UNSPECIFIED | Progres Q27/LF1 | Charles University | UNSPECIFIED |
|
PubMed ID: |
31046188 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/110887 |
Publisher's version: |
https://doi.org/10.1002/mds.27706 |
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