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One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi

Kanyama, C; Molloy, SF; Chan, AK; Lupiya, D; Chawinga, C; Adams, J; Bright, P; Lalloo, DG; Heyderman, RS; Lortholary, O; et al. Kanyama, C; Molloy, SF; Chan, AK; Lupiya, D; Chawinga, C; Adams, J; Bright, P; Lalloo, DG; Heyderman, RS; Lortholary, O; Jaffar, S; Loyse, A; van Oosterhout, JJ; Hosseinipour, MC; Harrison, TS (2020) One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi. Clin Infect Dis, 70 (3). pp. 521-524. ISSN 1537-6591 https://doi.org/10.1093/cid/ciz454
SGUL Authors: Molloy, Sile Harrison, Thomas Stephen

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Abstract

In Malawi, 236 participants from the Advancing Cryptococcal Meningitis Treatment for Africa trial were followed for 12 months. The trial outcomes reported at 10 weeks were sustained to 1 year. One-week amphotericin B plus flucytosine was associated with the lowest 1 year mortality (27.5% [95% confidence interval, 16.3 to 44.1]).

Item Type: Article
Additional Information: © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Cryptococcal meningitis, HIV, Malawi, long-term follow-up, treatment, 06 Biological Sciences, 11 Medical and Health Sciences, Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Clin Infect Dis
ISSN: 1537-6591
Language: eng
Dates:
DateEvent
1 February 2020Published
1 June 2019Published Online
30 May 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
100504Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
ANRS12275French Agency for Research on AIDS and Viral HepatitisUNSPECIFIED
PubMed ID: 31155650
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/110884
Publisher's version: https://doi.org/10.1093/cid/ciz454

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