SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Bronchiolitis: an update on management and prophylaxis.

Karampatsas, K; Kong, J; Cohen, J (2019) Bronchiolitis: an update on management and prophylaxis. Br J Hosp Med (Lond), 80 (5). pp. 278-284. ISSN 1750-8460 https://doi.org/10.12968/hmed.2019.80.5.278
SGUL Authors: Karampatsas, Konstantinos

[img]
Preview
PDF Accepted Version
Available under License ["licenses_description_publisher" not defined].

Download (1MB) | Preview

Abstract

Bronchiolitis is an acute respiratory illness that is the leading cause of hospitalization in young children less than 2 years of age in the UK. Respiratory syncytial virus is the most common virus associated with bronchiolitis and has the highest disease severity, mortality and cost. Bronchiolitis is generally a self-limiting condition, but can have serious consequences in infants who are very young, premature, or have underlying comorbidities. Management of bronchiolitis in the UK is guided by the National Institute for Health and Care Excellence (2015) guidance. The mainstays of management are largely supportive, consisting of fluid management and respiratory support. Pharmacological interventions including nebulized bronchodilators, steroids and antibiotics generally have limited or no evidence of efficacy and are not advised by National Institute of Health and Care Excellence. Antiviral therapeutics remain in development. As treatments are limited, there have been extensive efforts to develop vaccines, mainly targeting respiratory syncytial virus. At present, the only licensed product is a monoclonal antibody for passive immunisation. Its cost restricts its use to those at highest risk. Vaccines for active immunisation of pregnant women and young infants are also being developed.

Item Type: Article
Additional Information: This document is the Accepted Manuscript version of a Published Work that appeared in final form in British Journal of Hospital Medicine, copyright © MA Healthcare, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.12968/hmed.2019.80.5.278.
Keywords: 1103 Clinical Sciences, General & Internal Medicine
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Br J Hosp Med (Lond)
ISSN: 1750-8460
Language: eng
Dates:
DateEvent
2 May 2019Published
6 May 2019Published Online
18 December 2018Accepted
Publisher License: Publisher's own licence
PubMed ID: 31059347
Web of Science ID: WOS:000467024700029
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110874
Publisher's version: https://doi.org/10.12968/hmed.2019.80.5.278

Statistics

Item downloaded times since 29 May 2019.

Actions (login required)

Edit Item Edit Item