SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Fetal heart rate variability with hypoxemia in an instrumented sheep model.

Bhide, A; Johnson, J; Rasanen, J; Acharya, G (2019) Fetal heart rate variability with hypoxemia in an instrumented sheep model. Ultrasound Obstet Gynecol, 54 (6). pp. 786-790. ISSN 1469-0705 https://doi.org/10.1002/uog.20259
SGUL Authors: Bhide, Amarnath

[img]
Preview
PDF Accepted Version
Available under License ["licenses_description_publisher" not defined].

Download (286kB) | Preview

Abstract

Objective To examine the effect of hypoxemia on fetal heart rate (FHR) variability, using an instrumented pregnant sheep model. Methods In this prospective study, 19 pregnant sheep were instrumented under general anesthesia, at a mean gestational age of 127 days. After a 5‐day recovery period, hypoxemia was induced by attaching the mother to a rebreathing circuit. Hypoxemia was sustained for 120 min, following which it was reversed until maternal and fetal partial pressure of oxygen (pO2) returned to baseline. FHR recordings at baseline, after 30 and 120 min of hypoxemia and at recovery were analyzed to calculate short‐term variation (STV) in 16 epochs of 3.75 s, every minute. Phase‐rectified signal averaging (window length (L) = 10, time (T) = 2 and scale (S) = 2) was used to calculate FHR acceleration (AC) and deceleration (DC) capacities. Results At baseline, mean ± SD fetal pO2 was 2.90 ± 0.38 kPa. Acute hypoxemia was associated with a significant reduction in mean pO2 at 30 (1.62 ± 0.37 kPa) and 120 (1.51 ± 0.16 kPa) min. Mean ± SD fetal pO2 at recovery was 2.86 ± 0.32 kPa. At baseline, median STV, AC and DC were 1.307 (interquartile range (IQR), 0.515–2.508) ms, 1.295 (IQR, 0.990–2.685) beats per minute (bpm) and 1.197 (IQR, 0.850–1.836) bpm, respectively. At 30 min of hypoxemia, the values were 1.323 (IQR, 0.753–2.744) ms, 1.696 (IQR, 1.310–3.013) bpm and 1.584 (IQR, 1.217–4.132) bpm, respectively. At 120 min of hypoxemia, they were 1.760 (IQR, 0.928–4.656) ms, 3.098 (IQR, 1.530–5.163) bpm and 3.054 (IQR, 1.508–4.522) bpm, respectively. At recovery, they changed to 0.962 (IQR, 0.703–1.154) ms, 1.228 (IQR, 1.071–2.234) bpm and 1.086 (IQR, 0.873–1.568) bpm, respectively. Hypoxemia for 30 and 120 min was associated with a significant increase in DC compared to baseline (P = 0.014 and 0.017, respectively). The changes in STV and AC were not significant. Conclusion Acute hypoxemia is associated with a significant increase in the DC of FHR in a fetal sheep model.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Bhide, A., Johnson, J., Rasanen, J. and Acharya, G. (2019), Fetal heart rate variability with hypoxemia in an instrumented sheep model. Ultrasound Obstet Gynecol, 54: 786-790, which has been published in final form at https://doi.org/10.1002/uog.20259. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Keywords: Cardiotocography, Experimental Animal Model, Fetal, Heart Rate, Hypoxaemia, 1114 Paediatrics And Reproductive Medicine, Obstetrics & Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Vascular & Cardiac Surgery (INCCVC)
Journal or Publication Title: Ultrasound Obstet Gynecol
ISSN: 1469-0705
Language: eng
Dates:
DateEvent
4 December 2019Published
13 March 2019Published Online
1 March 2019Accepted
Publisher License: Publisher's own licence
PubMed ID: 30868659
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110868
Publisher's version: https://doi.org/10.1002/uog.20259

Actions (login required)

Edit Item Edit Item