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Neural Competitive Queuing of Ordinal Structure Underlies Skilled Sequential Action.

Kornysheva, K; Bush, D; Meyer, SS; Sadnicka, A; Barnes, G; Burgess, N (2019) Neural Competitive Queuing of Ordinal Structure Underlies Skilled Sequential Action. Neuron, 101 (6). 1166-1180.e3. ISSN 1097-4199 https://doi.org/10.1016/j.neuron.2019.01.018
SGUL Authors: Sadnicka, Anna

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Abstract

Fluent retrieval and execution of movement sequences is essential for daily activities, but the neural mechanisms underlying sequence planning remain elusive. Here participants learned finger press sequences with different orders and timings and reproduced them in a magneto-encephalography (MEG) scanner. We classified the MEG patterns for each press in the sequence and examined pattern dynamics during preparation and production. Our results demonstrate the "competitive queuing" (CQ) of upcoming action representations, extending previous computational and non-human primate recording studies to non-invasive measures in humans. In addition, we show that CQ reflects an ordinal template that generalizes across specific motor actions at each position. Finally, we demonstrate that CQ predicts participants' production accuracy and originates from parahippocampal and cerebellar sources. These results suggest that the brain learns and controls multiple sequences by flexibly combining representations of specific actions and interval timing with high-level, parallel representations of sequence position.

Item Type: Article
Additional Information: © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: 1109 Neurosciences, 1702 Cognitive Science, Neurology & Neurosurgery
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Neuron
ISSN: 1097-4199
Language: eng
Dates:
DateEvent
20 March 2019Published
7 February 2019Published Online
14 January 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
202805/Z/16/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
098881/Z/12/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 30744987
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110802
Publisher's version: https://doi.org/10.1016/j.neuron.2019.01.018

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