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Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis, and eczema in school children: ISAAC Phase Three

Morales, E; Strachan, DP; Asher, I; Ellwood, P; Pearce, N; García-Marcos, L; ISAAC Phase Three Study Group, (2019) Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis, and eczema in school children: ISAAC Phase Three. THORAX. ISSN 0040-6376 (In Press)
SGUL Authors: Strachan, David Peter

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[img] PDF Accepted Version
Restricted to Repository staff only until 28 February 2020.
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Abstract

Background: Asthma is not the key focus of prevention strategies. A healthy lifestyle index (HLI) was developed to examine the combined effect of modifiable lifestyle factors on asthma, rhinoconjunctivitis, and eczema using data from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three. Methods: Information on symptoms of asthma, rhinoconjunctivitis, eczema and several lifestyle factors was obtained from children aged 6–7 years through written questionnaires. The HLI combined five lifestyle factors: no parental smoking, child’s adherence to Mediterranean diet, child’s healthy body mass index, high physical activity and non-sedentary behaviour. The association between the HLI and risk of asthma, rhinoconjunctivitis, and eczema was evaluated using multilevel mixed-effects logistic regression models. Findings: Data of 70795 children from 37 centres in 19 countries were analysed. Each additional healthy lifestyle factor was associated with a reduced risk of current wheeze (OR=0.87, 95% CI 0.84-0.89), asthma ever (OR=0.89, 95% CI 0.87-0.92), current symptoms of rhinoconjunctivitis (OR=0.95, 95% CI 0.92-0.97), and current symptoms of eczema (OR=0.92, 95% CI 0.92-0.98). If associations were causal, a combination of four or five healthy lifestyle factors would result into a reduction up to 16% of asthma cases (ranging from 2.7 to 26.3% according to region of the world). Conclusions: Although causality cannot be established from this study, results suggest that interventions to improve multiple modifiable lifestyle factors should be considered and their efficacy assessed to reduce the burden asthma and allergy in childhood.

Item Type: Article
Keywords: 1103 Clinical Sciences, Respiratory System
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: THORAX
ISSN: 0040-6376
Dates:
DateEvent
11 February 2019Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
MS14/00046Miguel Servet Grant FellowshipUNSPECIFIED
URI: http://openaccess.sgul.ac.uk/id/eprint/110652

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