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Insight into the impact of vitamin D on cardiovascular outcomes in chronic kidney disease

Junarta, J; Jha, V; Banerjee, D (2019) Insight into the impact of vitamin D on cardiovascular outcomes in chronic kidney disease. Nephrology (Carlton). ISSN 1440-1797
SGUL Authors: Banerjee, Debasish

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Patients with chronic kidney disease (CKD) experience excess cardiovascular morbidity and mortality that is unexplained by traditional cardiovascular risk factors. Vitamin D deficiency is highly prevalent in CKD and is associated with increased cardiovascular mortality in both the general population and in CKD patients. Vitamin D supplementation is a reasonably safe and simple intervention and meta‐analyses of observational studies have suggested that vitamin D supplementation in CKD improves cardiovascular mortality. However, randomized controlled trials examining the impact of vitamin D supplementation in improving surrogate markers of cardiovascular structure and function remain inconclusive. This review investigates the impact of vitamin D supplementation on surrogate end‐points and cardiovascular events from trials in CKD; and discusses why results have been heterogenous, particularly critiquing the effect of different dosing regimens and the failure to take into account the implications of vitamin D supplementation in study participants with differing vitamin D binding protein genotypes.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Junarta, J. , Jha, V. and Banerjee, D. (2019), Insight into the impact of vitamin D on cardiovascular outcomes in chronic kidney disease. Nephrology, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Keywords: cardiovascular disease, chronic kidney disease, endothelial function, flow-mediated dilatation, vitamin D, 1103 Clinical Sciences, Urology & Nephrology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Nephrology (Carlton)
ISSN: 1440-1797
Language: eng
2 May 2019Published Online
21 January 2019Accepted
Publisher License: Publisher's own licence
Project IDFunderFunder ID
UNSPECIFIEDBritish Heart Foundation
UNSPECIFIEDBritish Renal Society
PubMed ID: 30684283
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