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Zinc cream and reliability of tuberculosis skin testing.

Rao, VB; Pelly, TF; Gilman, RH; Cabrera, L; Delgado, J; Soto, G; Friedland, JS; Escombe, AR; Black, RE; Evans, CA (2007) Zinc cream and reliability of tuberculosis skin testing. Emerg Infect Dis, 13 (7). pp. 1101-1104. ISSN 1080-6040 https://doi.org/10.3201/eid1307.070227
SGUL Authors: Friedland, Jonathan Samuel

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Abstract

In 50 healthy Peruvian shantytown residents, zinc cream applied to tuberculosis skin-test sites caused a 32% increase in induration compared with placebo cream. Persons with lower plasma zinc had smaller skin-test reactions and greater augmentation with zinc cream. Zinc deficiency caused false-negative skin-test results, and topical zinc supplementation augmented antimycobacterial immune responses enough to improve diagnosis.

Item Type: Article
Keywords: Administration, Topical, Adult, Diagnosis, Differential, Double-Blind Method, False Negative Reactions, Female, Humans, Male, Nutritional Status, Peru, Reproducibility of Results, Risk Factors, Sensitivity and Specificity, Skin, Social Class, Socioeconomic Factors, Trace Elements, Tuberculin Test, Tuberculosis, Zinc, Skin, Humans, Tuberculosis, Zinc, Trace Elements, Diagnosis, Differential, False Negative Reactions, Tuberculin Test, Administration, Topical, Risk Factors, Sensitivity and Specificity, Double-Blind Method, Reproducibility of Results, Nutritional Status, Social Class, Socioeconomic Factors, Adult, Peru, Female, Male, Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, MALNUTRITION, 1108 Medical Microbiology, 1117 Public Health And Health Services, 1103 Clinical Sciences, Microbiology
Journal or Publication Title: Emerg Infect Dis
ISSN: 1080-6040
Language: eng
Dates:
DateEvent
July 2007Published
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
UNSPECIFIEDWellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 18214192
Web of Science ID: WOS:000247758200027
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/110605
Publisher's version: https://doi.org/10.3201/eid1307.070227

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