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Physical frailty in older men: prospective associations with diet quality and patterns.

Parsons, TJ; Papachristou, E; Atkins, JL; Papacosta, O; Ash, S; Lennon, LT; Whincup, PH; Ramsay, SE; Wannamethee, SG (2019) Physical frailty in older men: prospective associations with diet quality and patterns. Age Ageing. ISSN 1468-2834 https://doi.org/10.1093/ageing/afy216
SGUL Authors: Whincup, Peter Hynes

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Abstract

Background: increasing numbers of older adults are living with frailty and its adverse consequences. We investigated relationships between diet quality or patterns and incident physical frailty in older British men and whether any associations were influenced by inflammation. Methods: prospective study of 945 men from the British Regional Heart Study aged 70-92 years with no prevalent frailty. Incident frailty was assessed by questionnaire after 3 years of follow-up. Frailty was defined as having at least three of: low grip strength, low physical activity, slow walking speed, unintentional weight loss and feeling of low energy, all based on self-report. The Healthy Diet Indicator (HDI) based on WHO dietary guidelines and the Elderly Dietary Index (EDI) based on a Mediterranean-style dietary intake were computed from questionnaire data and three dietary patterns were identified using principal components analysis: prudent, high fat/low fibre and high sugar. Results: men in the highest EDI category and those who followed a prudent diet were less likely to become frail [top vs bottom category odds ratio (OR) (95% CI) 0.49 (0.30, 0.82) and 0.53 (0.30, 0.92) respectively] after adjustment for potential confounders including BMI and prevalent cardiovascular disease. No significant association was seen for the HDI. By contrast those who had a high fat low fibre diet pattern were more likely to become frail [OR (95% CI) 2.54 (1.46, 4.40)]. These associations were not mediated by C-reactive protein (marker of inflammation). Conclusions: the findings suggest adherence to a Mediterranean-style diet is associated with reduced risk of developing frailty in older people.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Age and Ageing following peer review. The version of record Tessa J Parsons, Efstathios Papachristou, Janice L Atkins, Olia Papacosta, Sarah Ash, Lucy T Lennon, Peter H Whincup, Sheena E Ramsay, S Goya Wannamethee; Physical frailty in older men: prospective associations with diet quality and patterns, Age and Ageing, , afy216 is available online at: https://doi.org/10.1093/ageing/afy216
Keywords: 1103 Clinical Sciences, 1701 Psychology, 1117 Public Health And Health Services, Geriatrics
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Age Ageing
ISSN: 1468-2834
Language: eng
Dates:
DateEvent
22 January 2019Published Online
27 November 2018Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
R419/0515Dunhill Medical Trusthttp://dx.doi.org/10.13039/501100000377
R396/1114Dunhill Medical Trusthttp://dx.doi.org/10.13039/501100000377
RG/13/16/30528British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
PG09/024British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
PubMed ID: 30668624
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/110598
Publisher's version: https://doi.org/10.1093/ageing/afy216

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