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Comparative genomics of the major parasitic worms

Coghlan, A; Tyagi, R; Cotton, JA; Holroyd, N; Rosa, BA; Tsai, IJ; Laetsch, DR; Beech, RN; Day, TA; Hallsworth-Pepin, K; et al. Coghlan, A; Tyagi, R; Cotton, JA; Holroyd, N; Rosa, BA; Tsai, IJ; Laetsch, DR; Beech, RN; Day, TA; Hallsworth-Pepin, K; Ke, H-M; Kuo, T-H; Lee, TJ; Martin, J; Maizels, RM; Mutowo, P; Ozersky, P; Parkinson, J; Reid, AJ; Rawlings, ND; Ribeiro, DM; Swapna, LS; Stanley, E; Taylor, DW; Wheeler, NJ; Zamanian, M; Zhang, X; Allan, F; Allen, JE; Asano, K; Babayan, SA; Bah, G; Beasley, H; Bennett, HM; Bisset, SA; Castillo, E; Cook, J; Cooper, PJ; Cruz-Bustos, T; Cuellar, C; Devaney, E; Doyle, SR; Eberhard, ML; Emery, A; Eom, KS; Gilleard, JS; Gordon, D; Harcus, Y; Harsha, B; Hawdon, JM; Hill, DE; Hodgkinson, J; Horak, P; Howe, KL; Huckvale, T; Kalbe, M; Kaur, G; Kikuchi, T; Koutsovoulos, G; Kumar, S; Leach, AR; Lomax, J; Makepeace, B; Matthews, JB; Muro, A; O'Boyle, NM; Olson, PD; Osuna, A; Partono, F; Pfarr, K; Rinaldi, G; Foronda, P; Rollinson, D; Gomez Samblas, M; Sato, H; Schnyder, M; Scholz, T; Shafie, M; Tanya, VN; Toledo, R; Tracey, A; Urban, JF; Wang, L-C; Zarlenga, D; Blaxter, ML; Mitreva, M; Berriman, M; Consortium, IHG (2019) Comparative genomics of the major parasitic worms. NATURE GENETICS, 51 (1). pp. 163-174. ISSN 1061-4036
SGUL Authors: Cooper, Philip John

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Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report a broad comparative study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritized new potential drug targets and compounds for testing. This comparative genomics resource provides a much-needed boost for the research community to understand and combat parasitic worms.

Item Type: Article
Additional Information: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit © The Author(s) 2018
Keywords: 11 Medical And Health Sciences, 06 Biological Sciences, Developmental Biology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: NATURE GENETICS
ISSN: 1061-4036
January 2019Published
5 November 2018Published Online
24 September 2018Accepted
Publisher License: Creative Commons: Attribution 4.0
Project IDFunderFunder ID
206194Wellcome Trust
MR/L001020/1Medical Research Council
BB/K020048/1Biotechnology and Biological Sciences Research Council
U54HG003079National Human Genome Research Institute
AI081803National Institute of Allergy and Infectious Diseases
GM097435National Institute of General Medical Sciences
MR/K01207X/1Medical Research Council
R21 AI126466National Institutes of Health
RGPIN-2014-06664Natural Sciences and Engineering Research Council of Canada
106122Wellcome Trust
104111Wellcome Trust
60077344Institute of ParasitologyUNSPECIFIED
WT104104/Z/14/ZWellcome Trust
104958Wellcome Trust
Web of Science ID: WOS:000454108800023
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