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The effects of diabetes on tuberculosis treatment outcomes: an updated systematic review and meta-analysis

Huangfu, P; Ugarte-Gil, C; Golub, J; Pearson, F; Critchley, J (2019) The effects of diabetes on tuberculosis treatment outcomes: an updated systematic review and meta-analysis. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE. ISSN 1027-3719 (In Press)
SGUL Authors: Huangfu, Peijue

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Background Previous evidence synthesis has suggested diabetes mellitus (DM) worsens tuberculosis (TB) treatment outcomes. However, these reviews are limited by the number, robustness and conflicting results among the studies included. We conducted a systematic review to update earlier analyses and to explore heterogeneity between studies. Methods MEDLINE, EMBASE, AIM, LILACS, IMEMR, IMSEAR and WPRIM were searched between 1/1/1980 and 23/07/2018 unrestricted by language or region. All cohort and case-control studies investigating the difference in TB treatment outcomes amongst TB-DM patients compared to those with TB alone were included. Two reviewers independently assessed titles, abstracts, and extracted data. Culture conversion at two/three months, all-cause mortality, treatment failure, relapse, and multi-drug resistant TB (MDR-TB) were evaluated using random effects meta-analysis with generic inverse variance. Heterogeneity was explored using sub-group analyses and meta-regression. [PROSPERO ID: CRD42015026927] Results One hundred and four publications were identified. Sixty four studies including 56,122 individuals with TB-DM and 243,035 with TB, reported on death. Some outcomes showed substantial heterogeneity between studies which we could not fully explain though confounding adjustment and country income level accounted for some of the differences. TB-DM patients had higher odds of death (Odds ratio(OR)=1.88, 95%CI: 1.59-2.21) and relapse (OR=1.64, 95%CI: 1.29-2.08) compared to TB patients. More limited evidence suggested TB-DM patients had double the risk of developing MDR-TB (OR=1.98, 95%CI: 1.51-2.60). Conclusions DM is associated with increased risks of poor TB treatment outcomes, particularly mortality, and may increase risk of developing primary MDR-TB. Cost-effectiveness of interventions to enhance TB-DM treatment should be assessed.

Item Type: Article
Keywords: 1102 Cardiovascular Medicine And Haematology, Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
ISSN: 1027-3719
8 January 2019Accepted
Publisher License: Publisher's own licence
Project IDFunderFunder ID
7-627-3-167Qatar National Research FundUNSPECIFIED
D43TW00976301National Institutes of Health

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