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Does total volume of physical activity matter more than pattern for onset of CVD? A prospective cohort study of older British men.

Jefferis, BJ; Parsons, TJ; Sartini, C; Ash, S; Lennon, LT; Papacosta, O; Morris, RW; Wannamethee, SG; Lee, I-M; Whincup, PH (2019) Does total volume of physical activity matter more than pattern for onset of CVD? A prospective cohort study of older British men. Int J Cardiol, 278. pp. 267-272. ISSN 1874-1754 https://doi.org/10.1016/j.ijcard.2018.12.024
SGUL Authors: Whincup, Peter Hynes

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Abstract

AIMS: With increasing age, physical inactivity and sedentary behaviour levels increase, as does cardiovascular disease (CVD) incidence. We investigate how device-measured sedentary behaviour and physical activity (PA) are related to CVD onset in men aged 70+; whether the total volume of activity is more important than pattern. METHODS AND RESULTS: Prospective population-based cohort study of men recruited from 24 UK General Practices in 1978-80. In 2010-12, 3137 survivors were invited to complete questionnaires and wear an Actigraph GT3x accelerometer for 7 days. PA intensity was categorised as sedentary, light and moderate to vigorous (MVPA). Men were followed up for Myocardial Infarction, stroke and heart failure (ICD9 410-414, 430-438 and 428) morbidity and mortality from 2010 to 12 to June 2016. Hazard Ratios (HRs) for incident Cardiovascular Disease (CVD) were estimated. 1528/3137 (49%) men had sufficient accelerometer data. 254 men with pre-existing CVD were excluded. Participants' mean age was 78.4 (range 71-92) years. After median 4.9 years follow-up, 122 first CVD events occurred in 1181 men (22.7/1000 person-years) with complete data. For each additional 30 min in sedentary behaviour, light PA,10 min in MVPA, or 1000 steps/day, HRs for CVD were 1.09(95%CI 1.00, 1.19), 0.94(0.85, 1.04), 0.88(0.81, 0.96) and 0.86(0.78 to 0.95) respectively, adjusted for measurement-related factors, socio-demographics, health behaviours and disability. HRs for accumulating 150 min/week MVPA in bouts ≥1 min and bouts ≥10 min were 0.47(0.32 to 0.69), and 0.49(0.25, 0.98). CONCLUSIONS: In older men, high volume of steps or MVPA rather than MVPA bouts was associated with reduced CVD risk.

Item Type: Article
Additional Information: © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Accelerometer, CHD, Heart failure, Physical activity, Sedentary behaviour, Stroke, Accelerometer, CHD, Heart failure, Physical activity, Sedentary behaviour, Stroke, 1102 Cardiovascular Medicine And Haematology, Cardiovascular System & Hematology
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Int J Cardiol
ISSN: 1874-1754
Language: eng
Dates:
DateEvent
1 March 2019Published
13 December 2018Published Online
6 December 2018Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
PG/13/86/30546British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
RG/13/16/30528British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
PubMed ID: 30578094
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/110501
Publisher's version: https://doi.org/10.1016/j.ijcard.2018.12.024

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