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The cGMP-Degrading Enzyme Phosphodiesterase-5 (PDE5) in Cerebral Small Arteries of Older People

Vasita, E; Yasmeen, S; Andoh, J; Bridges, LR; Kruuse, C; Pauls, MMH; Pereira, A; Hainsworth, AH (2019) The cGMP-Degrading Enzyme Phosphodiesterase-5 (PDE5) in Cerebral Small Arteries of Older People. JNEN, 78 (2). pp. 191-194. ISSN 0022-3069 https://doi.org/10.1093/jnen/nly117
SGUL Authors: Hainsworth, Atticus Henry

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Abstract

Cerebral small vessel disease in deep penetrating arteries is a major cause of lacunar infarcts, white matter lesions and vascular cognitive impairment. Local cerebral blood flow in these small vessels is controlled by endothelial-derived nitric oxide, which exerts a primary vasodilator stimulus on vascular myocytes, via cytoplasmic cyclic GMP. Here, we investigated whether the cGMP-degrading enzyme phosphodiesterase-5 (PDE5) is present in small penetrating arteries in the deep subcortical white matter of older people. Frontal cortical tissue blocks were examined from donated brains of older people (n = 42, 24 male: 18 female, median age 81, range: 59–100 years). PDE5, detected by immunohistochemical labeling, was graded as absent, sparse, or abundant in vascular cells within small arteries in subcortical white matter (vessel outer diameter: 20–100 µm). PDE5 labeling within arterial myocytes was detected in all cases. Degree of PDE5 expression (absent, sparse, or abundant) was not associated with age or with neuropathological diagnosis of small vessel disease. In conclusion, PDE5 is present in vascular myocytes within small penetrating arteries in older people. This is a potential molecular target for pharmacological interventions.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Neuropathology and Experimental Neurology following peer review. The version of record Ekta Vasita, Saiqa Yasmeen, Joycelyn Andoh, Leslie R Bridges, Christina Kruuse, Mathilde M H Pauls, Anthony C Pereira, Atticus H Hainsworth; The cGMP-Degrading Enzyme Phosphodiesterase-5 (PDE5) in Cerebral Small Arteries of Older People, Journal of Neuropathology & Experimental Neurology, Volume 78, Issue 2, 1 February 2019, Pages 191–194 is available online at: https://doi.org/10.1093/jnen/nly117
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: JNEN
ISSN: 0022-3069
Dates:
DateEvent
1 February 2019Published
26 December 2018Published Online
13 November 2018Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
PG146/151Alzheimer's Society (UK)UNSPECIFIED
20140901Alzheimer's Drug Discovery FoundationUNSPECIFIED
PPG2014A-8Alzheimer's Research UKUNSPECIFIED
G1000691Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
URI: http://openaccess.sgul.ac.uk/id/eprint/110372
Publisher's version: https://doi.org/10.1093/jnen/nly117

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