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Cardiac maladaptation in term pregnancies with preeclampsia.

Buddeberg, BS; Sharma, R; O'Driscoll, JM; Kaelin Agten, A; Khalil, A; Thilaganathan, B (2018) Cardiac maladaptation in term pregnancies with preeclampsia. Pregnancy Hypertens, 13. pp. 198-203. ISSN 2210-7797 https://doi.org/10.1016/j.preghy.2018.06.015
SGUL Authors: Thilaganathan, Baskaran Khalil, Asma

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Abstract

OBJECTIVES: To study biventricular cardiac changes with conventional echocardiography and new echocardiographic speckle tracking technologies such strain, twist and torsion in pregnant women with preeclampsia at term and normotensive control term pregnant women. STUDY DESIGN: For this prospective single centre case-control study, we consecutively recruited 30 women with preeclampsia at term as cases and 40 healthy control term pregnant women. All women underwent transthoracic echocardiographic examination at the time point of inclusion into the study. MAIN OUTCOME MEASURES: Signs of systolic and/or diastolic cardiac maladaptation to the increased volume load associated with pregnancy. RESULTS: Conventional echocardiography revealed mild left sided diastolic impairment in the form of significantly increased E/E' in preeclampsia (7.58 ± 1.72 vs. 6.18 ± 1.57, p = 0.001) compared to normotensive controls, but no evidence of systolic impairment. With speckle tracking analysis, significant decreases in left ventricular global (-13.32 ± 2.37% vs. -17.61 ± 1.89%, p < 0.001), endocardial (-15.64 ± 2.79% vs. -19.84 ± 2.35%, p < 0.001) and epicardial strain (-11.48 ± 2.15% vs. -15.73 ± 1.66%, p < 0.001) as well as left ventricular longitudinal strain rate (-0.84 ± 0.14 s-1 vs. -0.98 ± 0.12 s-1, p < 0.001) and left ventricular early diastolic strain rate (0.86 ± 0.30 s-1 vs. 1.24 ± 0.26 s-1, p < 0.001) could be observed in women with term preeclampsia. CONCLUSIONS: The findings of this study demonstrate that pregnant women with term preeclampsia with minimal functional changes on conventional echocardiography, demonstrated significant subclinical myocardial changes on speckle tracking analysis.

Item Type: Article
Additional Information: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Cardiac dysfunction, Echocardiography, Preeclampsia, Pregnancy, Speckle tracking, Pregnancy, Preeclampsia, Echocardiography, Speckle tracking, Cardiac dysfunction, Cardiac dysfunction, Echocardiography, Preeclampsia, Pregnancy, Speckle tracking
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Pregnancy Hypertens
ISSN: 2210-7797
Language: eng
Dates:
DateEvent
July 2018Published
23 June 2018Published Online
23 June 2018Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 30177052
Web of Science ID: WOS:000443326700034
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110319
Publisher's version: https://doi.org/10.1016/j.preghy.2018.06.015

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