Shrine, N;
Guyatt, AL;
Erzurumluoglu, AM;
Jackson, VE;
Hobbs, BD;
Melbourne, C;
Batini, C;
Fawcett, KA;
Song, K;
Sakornsakolpat, P;
et al.
Shrine, N; Guyatt, AL; Erzurumluoglu, AM; Jackson, VE; Hobbs, BD; Melbourne, C; Batini, C; Fawcett, KA; Song, K; Sakornsakolpat, P; Li, X; Boxall, R; Reeve, NF; Obeidat, M; Zhao, JH; Wielscher, M; Understanding Society Scientific Group; Weiss, S; Kentistou, KA; Cook, JP; Sun, BB; Zhou, J; Hui, J; Karrasch, S; Imboden, M; Harris, SE; Marten, J; Enroth, S; Kerr, SM; Surakka, I; Vitart, V; Lehtimäki, T; Allen, RJ; Bakke, PS; Beaty, TH; Bleecker, ER; Bossé, Y; Brandsma, C-A; Chen, Z; Crapo, JD; Danesh, J; DeMeo, DL; Dudbridge, F; Ewert, R; Gieger, C; Gulsvik, A; Hansell, AL; Hao, K; Hoffman, JD; Hokanson, J; Homuth, G; Joshi, PK; Joubert, P; Langenberg, C; Li, X; Li, L; Lin, K; Lind, L; Locantore, N; Luan, J; Mahajan, A; Maranville, JC; Murray, A; Nickle, DC; Packer, R; Parker, MM; Paynton, ML; Porteous, D; Prokopenko, D; Qiao, D; Rawal, R; Runz, H; Sayers, I; Sin, DD; Smith, BH; Soler Artigas, M; Sparrow, D; Tal-Singer, R; Timmers, PRHJ; Van de Berge, M; Whittaker, JC; Woodruff, P; Yerges Armstrong, LM; Troyanskaya, OG; Raitakari, OT; Kähönen, M; Polašek, O; Gyllensten, U; Rudan, I; Deary, IJ; Probst-Hensch, NM; Schulz, H; James, AL; Wilson, JF; Stubbe, B; Zeggini, E; Jarvelin, M-R; Wareham, N; Silverman, EK; Hayward, C; Morris, AP; Butterworth, AS; Scott, RA; Walters, RG; Meyers, DA; Cho, MH; Strachan, DP; Hall, IP; Tobin, MD; Wain, LV
(2019)
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
NATURE GENETICS, 51 (3).
pp. 481-493.
ISSN 1061-4036
https://doi.org/10.1038/s41588-018-0321-7
SGUL Authors: Strachan, David Peter
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Abstract
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function–associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.
| Item Type: | Article | ||||||
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| Additional Information: | This is a post-peer-review, pre-copyedit version of an article published in Nature Genetics. The final authenticated version is available online at: http://dx.doi.org/10.1038/s41588-018-0321-7 Correction available at https://doi.org/10.1038/s41588-019-0438-3 | ||||||
| Keywords: | 11 Medical And Health Sciences, 06 Biological Sciences, Developmental Biology | ||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Population Health Research Institute (INPH) | ||||||
| Journal or Publication Title: | NATURE GENETICS | ||||||
| ISSN: | 1061-4036 | ||||||
| Dates: |
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| Publisher License: | Publisher's own licence | ||||||
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/110268 | ||||||
| Publisher's version: | https://doi.org/10.1038/s41588-018-0321-7 |
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