SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Smoking status at diagnosis and subsequent smoking cessation: associations with corticosteroid use and intestinal resection in Crohn's disease

Alexakis, C; Saxena, S; Chhaya, V; Cecil, E; Majeed, A; Pollok, RCG (2018) Smoking status at diagnosis and subsequent smoking cessation: associations with corticosteroid use and intestinal resection in Crohn's disease. AMERICAN JOURNAL OF GASTROENTEROLOGY, 113 (11). pp. 1689-1700. ISSN 0002-9270 https://doi.org/10.1038/s41395-018-0273-7
SGUL Authors: Pollok, Richard Charles G

[img]
Preview
PDF Accepted Version
Available under License ["licenses_description_publisher" not defined].

Download (638kB) | Preview
[img] Microsoft Word (.docx) Accepted Version
Available under License ["licenses_description_publisher" not defined].

Download (8MB)

Abstract

Background The impact of smoking at diagnosis and subsequent smoking cessation on clinical outcomes in Crohn’s disease (CD) has not been evaluated in a population-based cohort. Methods Using a nationally representative clinical research database, we identified incident cases of CD between 2005 and 2014. We compared the following outcomes: overall corticosteroid (CS) use; flares requiring CS; CS dependency and intestinal surgery between smokers and non-smokers at time of CD diagnosis. Differences in these outcomes were also compared between persistent smokers and smokers who quit within 2 years of diagnosis. Results We identified 3553 patients with a new CD diagnosis over the study period of whom 1121 (32%) were smokers. Smokers at CD diagnosis had significantly higher CS-use (56 versus 47%, p < 0.0001), proportionally more CS flares (>1 CS flare/year: 9 versus 6%, p < 0.0001), and higher CS dependency (27 versus 21%, p < 0.0001) than non-smokers. Regression analysis identified smoking at diagnosis to be associated with a higher risk of intestinal surgery (HR 1.64, 95% CI 1.16–2.52). There was a significantly higher proportion of ‘quitters’ who remained steroid-free through follow-up in comparison to ‘persistent smokers’ (45.4 versus 37.5%, respectively, p = 0.02). ‘Quitters’ also had lower rates of CS dependency compared to ‘persistent smokers’ (24 versus 33%, p = 0.008). Conclusions Smokers at CD diagnosis have higher CS-use, CS dependency and higher risk of intestinal surgery. Quitting smoking appears to have beneficial effects on disease related outcomes, including reducing CS dependency highlighting the importance of offering early smoking cessation support.

Item Type: Article
Additional Information: This is a post-peer-review, pre-copyedit version of an article published in The American Journal of Gastroenterology. The final authenticated version is available online at: http://dx.doi.org/10.1038/s41395-018-0273-7
Keywords: 1103 Clinical Sciences, Gastroenterology & Hepatology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: AMERICAN JOURNAL OF GASTROENTEROLOGY
ISSN: 0002-9270
Dates:
DateEvent
November 2018Published
15 October 2018Published Online
10 August 2018Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
UNSPECIFIEDWellcome Trusthttp://dx.doi.org/10.13039/100004440
UNSPECIFIEDNational Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
UNSPECIFIEDMedical Research Councilhttp://dx.doi.org/10.13039/501100000265
URI: https://openaccess.sgul.ac.uk/id/eprint/110208
Publisher's version: https://doi.org/10.1038/s41395-018-0273-7

Actions (login required)

Edit Item Edit Item