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Perinatal mortality, timing of delivery and prenatal management of monoamniotic twin pregnancy: systematic review and meta‐analysis

D'Antonio, F; Odibo, A; Berghella, V; Khalil, A; Hack, K; Saccone, G; Prefumo, F; Buca, D; Liberati, M; Pagani, G; et al. D'Antonio, F; Odibo, A; Berghella, V; Khalil, A; Hack, K; Saccone, G; Prefumo, F; Buca, D; Liberati, M; Pagani, G; Acharya, G (2019) Perinatal mortality, timing of delivery and prenatal management of monoamniotic twin pregnancy: systematic review and meta‐analysis. Ultrasound Obstet Gynecol, 53 (2). pp. 166-174. ISSN 1469-0705 https://doi.org/10.1002/uog.20100
SGUL Authors: Khalil, Asma

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Abstract

Objective To quantify the rate of perinatal mortality in monochorionic monoamniotic (MCMA) twin pregnancies, according to gestational age, and to ascertain the incidence of mortality in pregnancies managed as inpatients compared with those managed as outpatients. Methods MEDLINE, EMBASE and CINAHL databases were searched for studies on monoamniotic twin pregnancy. The primary outcomes explored were the incidence of intrauterine death (IUD), neonatal death (NND) and perinatal death (PND) in MCMA twins at different gestational‐age windows (24–30, 31–32, 33–34, 35–36 and ≥ 37 weeks of gestation). The secondary outcomes were the incidence of IUD, NND and PND in MCMA twins according to the type of fetal monitoring (inpatient vs outpatient), and the incidence of delivery ahead of schedule. Random‐effects model meta‐analyses were used to analyze the data. Results Twenty‐five studies (1628 non‐anomalous twins reaching 24 weeks of gestation) were included. Single and double intrauterine deaths occurred in 2.5% (95% CI, 1.8–3.3%) and 3.8% (95% CI, 2.5–5.3%) of cases, respectively. IUD occurred in 4.3% (95% CI, 2.8–6.2%) of twins at 24–30 weeks, in 1.0% (95% CI, 0.6–1.7%) at 31–32 weeks and in 2.2% (95% CI, 0.9–3.9%) at 33–34 weeks of gestation, while there was no case of IUD, either single or double, from 35 weeks of gestation. In MCMA twin pregnancies managed mainly as inpatients, the incidence of IUD was 3.0% (95% CI, 1.4–5.2%), while the corresponding figure for those managed mainly as outpatients was 7.4% (95% CI, 4.4–11.1%). Finally, 37.8% (95% CI, 28.0–48.2%) of MCMA pregnancies were delivered before the scheduled time, due mainly to spontaneous preterm labor or abnormal cardiotocographic findings. Conclusions MCMA twins are at high risk of perinatal loss during the third trimester of pregnancy, with the large majority of such losses occurring as apparently unexpected events. Inpatient management seems to be associated with a lower rate of mortality, although further studies are needed in order to establish the appropriate type and timing of prenatal assessment in these pregnancies.

Item Type: Article
Additional Information: This is the pre-peer reviewed version of the following article: D'Antonio, F. , Odibo, A. , Berghella, V. , Khalil, A. , Hack, K. , Saccone, G. , Prefumo, F. , Buca, D. , Liberati, M. , Pagani, G. and Acharya, G. (2019), Perinatal mortality, timing of delivery and prenatal management of monoamniotic twin pregnancy: systematic review and meta‐analysis. Ultrasound Obstet Gynecol, 53: 166-174, which has been published in final form at https://doi.org/10.1002/uog.20100. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Keywords: Monoamniotic twin pregnancies, neonatal outcome, systematic review, timing of delivery, Obstetrics & Reproductive Medicine, 1114 Paediatrics And Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Ultrasound Obstet Gynecol
ISSN: 1469-0705
Language: eng
Dates:
DateEvent
5 February 2019Published
20 August 2018Published Online
27 July 2018Accepted
Publisher License: Publisher's own licence
PubMed ID: 30125418
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/110106
Publisher's version: https://doi.org/10.1002/uog.20100

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