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Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits

Evangelou, E; Warren, HR; Mosen-Ansorena, D; Mifsud, B; Pazoki, R; Gao, H; Ntrisos, G; Dimou, N; Cabrera, CP; Karaman, I; et al. Evangelou, E; Warren, HR; Mosen-Ansorena, D; Mifsud, B; Pazoki, R; Gao, H; Ntrisos, G; Dimou, N; Cabrera, CP; Karaman, I; Ng, FL; Evangelou, M; Witkowska, K; Tzanis, E; Hellwege, JN; Giri, A; Velez Edwards, DR; Sun, YV; Cho, K; Gaziano, JM; Wilson, PWF; Tsao, PS; Kovesdy, CP; Esko, T; Mägi, R; Milani, L; Almgren, P; Boutin, T; Debette, S; Ding, J; Giulianini, F; Holliday, EG; Jackson, AU; Li-Gao, R; Lin, W-Y; Luan, J; Mangino, M; Oldmeadow, C; Prins, BP; Qian, Y; Sargurupremraj, M; Shah, N; Surendran, P; Thériault, S; Verweij, N; Willems, SM; Zhao, J-H; Amouyel, P; Connell, J; de Mutsert, R; Doney, ASF; Farrall, M; Menni, C; Morris, AD; Noordam, R; Paré, G; Poulter, NR; Shields, DC; Stanton, A; Thom, S; Abecasis, G; Amin, N; Arking, DE; Ayers, KL; Barbieri, CM; Batini, C; Bis, JC; Blake, T; Bochud, M; Boehnke, M; Boerwinkle, E; Boomsma, DI; Bottinger, EP; Braund, PS; Brumat, M; Campbell, A; Campbell, H; Chakravarti, A; Chambers, JC; Chauhan, G; Ciullo, M; Cocca, M; Collins, F; Cordell, HJ; Davies, G; de Borst, MH; de Geus, EJ; Deary, IJ; Deelan, J; Del Greco, F; Demirkale, CY; Dörr, M; Ehret, GB; Elosua, R; Enroth, S; Erzurumluoglu, AM; Ferreira, T; Frånberg, M; Franco, OH; Gandin, I; Gasparini, P; Giedraitis, V; Gieger, C; Girotto, G; Goel, A; Gow, AJ; Gudnason, V; Guo, X; Gyllensten, U; Hamsten, A; Harris, TB; Harris, SE; Hartman, CA; Havulinna, AS; Hicks, AA; Hofer, E; Hofman, A; Hottenga, J-J; Huffman, JE; Hwang, S-J; Ingelsson, E; James, A; Jansen, R; Jarvelin, M-R; Joehanes, R; Johansson, Å; Johnson, AD; Joshi, PK; Jousilahti, P; Jukema, JW; Jula, A; Kähönen, M; Kathiresan, S; Keavney, BD; Khaw, K-T; Knekt, P; Knight, J; Kolcic, I; Kooner, JS; Koskinen, S; Kristiansson, K; Kutalik, Z; Laan, M; Larson, M; Launer, LJ; Lehne, B; Lehtimäki, T; Liewald, DCM; Lin, L; Lind, L; Lindgren, CM; Liu, YM; Loos, RJF; Lopez, LM; Lu, Y; Lyytikäinen, L-P; Mahajan, A; Mamasoula, C; Marrugat, J; Marten, J; Milaneshi, Y; Morgan, A; Morris, AP; Morrison, AC; Munson, PJ; Nalls, MA; Nandakumar, P; Nelson, CP; Niiranen, T; Nolte, IM; Nutile, T; Oldehinkel, AJ; Oostra, BA; O'Rielly, PF; Org, E; Padmanabhan, S; Palmas, W; Palotie, A; Pattie, A; Penninx, BWJH; Perola, M; Peters, A; Polasek, O; Pramstaller, PP; Nguyen, QT; Raitakari, OT; Ren, M; Rettig, R; Rice, K; Ridker, PM; Ried, JS; Riese, H; Ripatti, S; Robino, A; Rose, LM; Rotter, JI; Rudan, I; Ruggiero, D; Saba, Y; Sala, CF; Salomaa, V; Samani, NJ; Sarin, A-P; Schmidt, R; Schmidt, H; Shrine, N; Siscovick, D; Smith, AV; Sneider, H; Sõber, S; Sorice, R; Starr, JM; Stott, DJ; Strachan, DP; Strawbridge, RJ; Sundström, J; Swertz, MA; Taylor, KD; Teumer, A; Tobin, MD; Tomaszewski, M; Toniolo, D; Traglia, M; Trompet, S; Tuomilehto, J; Tzourio, C; Uitterlinden, AG; Vaez, A; van der Most, PJ; van Duijn, CM; Vergnaud, A-C; Verwoert, GC; Vitart, V; Völker, U; Vollenweider, P; Vuckovic, D; Watkins, H; Wild, SH; Willemsen, G; Wilson, JF; Wright, AF; Yao, J; Zemunik, T; Zhang, W; Attia, JR; Butterworth, AS; Chasman, DI; Conen, D; Cucca, F; Danesh, J; Hayward, C; Howson, JMM; Laakso, M; Lakatta, EG; Langenberg, C; Melander, O; Mook-Kanamori, DO; Palmer, CNA; Risch, L; Scott, RA; Scott, RJ; Sever, P; Spector, TD; van der Harst, P; Wareham, NJ; Zeggini, E; Levy, D; Munroe, PB; Newton-Cheh, C; Brown, MJ; Metspalu, A; Hung, AM; O'Donnell, CJ; Edwards, TL; Million Veteran Program; Psaty, BM; Tzoulaki, I; Barnes, MR; Wain, LV; Elliott, P; Caulfield, MJ (2018) Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (10). pp. 1412-1425. ISSN 1546-1718 https://doi.org/10.1038/s41588-018-0205-x
SGUL Authors: Strachan, David Peter

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Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic, pulse pressure) to date in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Item Type: Article
Additional Information: This is a post-peer-review, pre-copyedit version of an article published in Nature Genetics. The final authenticated version is available online at: http://dx.doi.org/10.1038/s41588-018-0205-x Correction available at: http://doi.org/10.1038/s41588-018-0297-3
Keywords: Developmental Biology, 11 Medical And Health Sciences, 06 Biological Sciences
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Nature Genetics
ISSN: 1546-1718
Dates:
DateEvent
October 2018Published
17 September 2018Published Online
9 July 2018Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
MR/L01632X.1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/L016311/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/M016560/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
G1000143Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MC_UU_12015/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MC_PC_13048Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MC_U106179471Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
C864/A14136Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
090532/Z/09/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
RE/13/1/30181British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
PG/17/35/33001British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
WT098051Wellcome Trusthttp://dx.doi.org/10.13039/100004440
MR/L003120/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
RG/13/13/30194British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
MR/L01341X/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
SP/13/2/30111British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
MR/L01632X/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
G952010Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
G0000934Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
068545/Z/02Wellcome Trusthttp://dx.doi.org/10.13039/100004440
076113/B/04/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
079895Wellcome Trusthttp://dx.doi.org/10.13039/100004440
G9521010DWellcome Trusthttp://dx.doi.org/10.13039/100004440
G0800270Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
SP/09/002British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
RG/08/014British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
RG13/13/30194British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
BHF/RG/2000004British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
MR/K026992/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
SP/04/002British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
G0601966Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
G0700931Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
084723/Z/08/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
090532Wellcome Trusthttp://dx.doi.org/10.13039/100004440
098381Wellcome Trusthttp://dx.doi.org/10.13039/100004440
WT098017Wellcome Trusthttp://dx.doi.org/10.13039/100004440
WT090532Wellcome Trusthttp://dx.doi.org/10.13039/100004440
WT064890Wellcome Trusthttp://dx.doi.org/10.13039/100004440
URI: http://openaccess.sgul.ac.uk/id/eprint/109959
Publisher's version: https://doi.org/10.1038/s41588-018-0205-x

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