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Gender Differences in Patients with Brugada Syndrome and Arrhythmic Events: Data from a Survey on Arrhythmic Events in 678 Patients.

Milman, A; Gourraud, J-B; Andorin, A; Postema, PG; Sacher, F; Mabo, P; Conte, G; Giustetto, C; Sarquella-Brugada, G; Hochstadt, A; et al. Milman, A; Gourraud, J-B; Andorin, A; Postema, PG; Sacher, F; Mabo, P; Conte, G; Giustetto, C; Sarquella-Brugada, G; Hochstadt, A; Kim, S-H; Juang, JJ; Maeda, S; Takahashi, Y; Kamakura, T; Aiba, T; Leshem, E; Michowitz, Y; Rahkovich, M; Mizusawa, Y; Arbelo, E; Huang, Z; Denjoy, I; Wijeyeratne, YD; Napolitano, C; Brugada, R; Casado-Arroyo, R; Champagne, J; Calo, L; Tfelt-Hansen, J; Priori, SG; Takagi, M; Veltmann, C; Delise, P; Corrado, D; Behr, ER; Gaita, F; Yan, G-X; Brugada, J; Leenhardt, A; Wilde, AAM; Brugada, P; Kusano, KF; Hirao, K; Nam, G-B; Probst, V; Belhassen, B (2018) Gender Differences in Patients with Brugada Syndrome and Arrhythmic Events: Data from a Survey on Arrhythmic Events in 678 Patients. Heart Rhythm, 15 (10). pp. 1457-1465. ISSN 1556-3871 https://doi.org/10.1016/j.hrthm.2018.06.019
SGUL Authors: Behr, Elijah Raphael

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Abstract

BACKGROUND: There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVES: To compare clinical, electrocardiographic (ECG), electrophysiologic (EP) and genetic characteristics between males and females in BrS-patients with their first AE. METHODS: The multicenter Survey on AE in BrS (SABRUS) collected data on first AE in 678 BrS-patients including 619 (91.3%) males and 59 (8.7%) females aged 0.27 to 84 (mean 42.5±14.1) years at the time of AE. RESULTS: After excluding pediatric patients, females were older than males (49.5±14.4 vs. 43±12.7 years, respectively, P=0.001). Higher proportions of females were observed in the pediatric and elderly populations. In Asians, male/female ratio of AE was ≈9-fold higher compared to Caucasians. Spontaneous type 1 BrS-ECG was associated with earlier onset of AE in pediatric females. A similar prevalence (≈65%) of spontaneous type 1 BrS-ECG was present in males and females above age of 60 years. Females less frequently showed a spontaneous type-1 BrS-ECG (31% vs. 59%, P<0.001) or arrhythmia-inducibility at EP study (34% vs. 64%, P<0.001). An SCN5A mutation was more frequently found in females (47.6% vs. 27.8% in males, P=0.007). CONCLUSIONS: This study confirms that female BrS-patients are much rarer, display less type 1 Brugada-ECG and exhibit lower inducibility rates than males. It shows for the first time that BrS females with AE have higher SCN5A mutation rates as well as the relationship between gender vs. age at onset of AE and ethnicity.

Item Type: Article
Additional Information: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Brugada-ECG, Ethnicity, Implantable cardioverter defibrillator, SCN5A mutation, Sudden cardiac death, Cardiovascular System & Hematology, 1102 Cardiovascular Medicine And Haematology, 0903 Biomedical Engineering
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Heart Rhythm
ISSN: 1556-3871
Language: eng
Dates:
DateEvent
October 2018Published
13 June 2018Published Online
13 June 2018Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 29908370
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109908
Publisher's version: https://doi.org/10.1016/j.hrthm.2018.06.019

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