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Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort

Jackson, C; Southern, J; Lalvani, A; Drobniewski, F; Griffiths, CJ; Lipman, M; Bothamley, GH; Deeks, JJ; Imran, A; Kon, OM; et al. Jackson, C; Southern, J; Lalvani, A; Drobniewski, F; Griffiths, CJ; Lipman, M; Bothamley, GH; Deeks, JJ; Imran, A; Kon, OM; Mpofu, S; Nikolayevskyy, V; Rees-Roberts, M; Sitch, A; Sridhar, S; Tsou, C-Y; Whitworth, H; Abubakar, I (2019) Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort. Thorax, 74 (1). pp. 91-94. ISSN 0040-6376 https://doi.org/10.1136/thoraxjnl-2017-211124
SGUL Authors: Jackson, Charlotte Rebecca

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Abstract

We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025).

Item Type: Article
Additional Information: This article has been accepted for publication in Thorax following peer review. The definitive copyedited, typeset version Jackson C, Southern J, Lalvani A, et al Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort Thorax 2019;74:91-94 is available online at: http://dx.doi.org/10.1136/thoraxjnl-2017-211124
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Thorax
ISSN: 0040-6376
Dates:
DateEvent
January 2019Published
15 May 2018Published Online
9 April 2018Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
NIHR HTA 08/68/01National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
NIHR SRF-2011-04-001National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
NIHR NF-SI-0616-10037National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
URI: http://openaccess.sgul.ac.uk/id/eprint/109823
Publisher's version: https://doi.org/10.1136/thoraxjnl-2017-211124

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