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Ethnic differences in blood lipids and dietary intake between UK children of black African, black Caribbean, South Asian, and white European origin: the Child Heart and Health Study in England (CHASE).

Donin, AS; Nightingale, CM; Owen, CG; Rudnicka, AR; McNamara, MC; Prynne, CJ; Stephen, AM; Cook, DG; Whincup, PH (2010) Ethnic differences in blood lipids and dietary intake between UK children of black African, black Caribbean, South Asian, and white European origin: the Child Heart and Health Study in England (CHASE). Am J Clin Nutr, 92 (4). pp. 776-783. ISSN 1938-3207 https://doi.org/10.3945/ajcn.2010.29533
SGUL Authors: Cook, Derek Gordon Nightingale, Claire Owen, Christopher Grant Rudnicka, Alicja Regina Whincup, Peter Hynes Donin, Angela

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Abstract

BACKGROUND: Ischemic heart disease (IHD) rates are lower in UK black Africans and black Caribbeans and higher in South Asians when compared with white Europeans. Ethnic differences in lipid concentrations may play a part in these differences. OBJECTIVE: The objective was to investigate blood lipid and dietary patterns in UK children from different ethnic groups. DESIGN: This was a cross-sectional study in 2026 UK children (including 285 black Africans, 188 black Caribbeans, 534 South Asians, and 512 white Europeans) attending primary schools in London, Birmingham, and Leicester. We measured fasting blood lipid concentrations and collected 24-h dietary recalls. RESULTS: In comparison with white Europeans, black African children had lower total cholesterol (-0.14 mmol/L; 95% CI: -0.25, -0.04 mmol/L), LDL-cholesterol (-0.10 mmol/L; 95% CI: -0.20, -0.01 mmol/L), and triglyceride concentrations (proportional difference: -0.11 mmol/L; 95% CI: -0.16, -0.06 mmol/L); HDL-cholesterol concentrations were similar. Lower saturated fat intakes (-1.4%; 95% CI: -1.9%, -0.9%) explained the differences between total and LDL cholesterol. Black Caribbean children had total, LDL-cholesterol, HDL-cholesterol, and triglyceride concentrations similar to those for white Europeans, with slightly lower saturated fat intakes. South Asian children had total and LDL-cholesterol concentrations similar to those for white Europeans, lower HDL-cholesterol concentrations (-0.7 mmol/L; 95% CI: -0.11, -0.03 mmol/L), and elevated triglyceride concentrations (proportional difference: 0.14 mmol/L; 95% CI: 0.09, 0.20 mmol/L); higher polyunsaturated and monounsaturated fat intakes did not explain these lipid differences. CONCLUSIONS: Only black African children had a blood lipid profile and associated dietary pattern likely to protect against future IHD. The loss of historically lower LDL-cholesterol concentrations among UK black Caribbeans and South Asians may have important adverse consequences for future IHD risk in these groups.

Item Type: Article
Additional Information: © 2010 American Society for Nutrition
Keywords: African Continental Ancestry Group, Asian Continental Ancestry Group, Body Height, Body Weight, Child, Cholesterol, Cholesterol, LDL, Energy Intake, England, Ethnic Groups, European Continental Ancestry Group, Humans, Lipids, Myocardial Ischemia, Skinfold Thickness, Social Class, Triglycerides, United Kingdom, Humans, Myocardial Ischemia, Body Weight, Cholesterol, Lipids, Triglycerides, Body Height, Skinfold Thickness, Energy Intake, Social Class, Child, African Continental Ancestry Group, Asian Continental Ancestry Group, European Continental Ancestry Group, Ethnic Groups, Great Britain, England, Cholesterol, LDL, Science & Technology, Life Sciences & Biomedicine, Nutrition & Dietetics, NUTRITION & DIETETICS, RISK-FACTORS, CARDIOVASCULAR RISK, INSULIN-RESISTANCE, UNITED-KINGDOM, CORONARY RISK, DISEASE, LONDON, MEN, CHOLESTEROL, MORTALITY, Nutrition & Dietetics, 11 Medical And Health Sciences, 09 Engineering
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Am J Clin Nutr
ISSN: 1938-3207
Language: eng
Dates:
DateEvent
October 2010Published
25 August 2010Published Online
28 July 2010Accepted
Publisher License: Creative Commons: Attribution-Noncommercial 4.0
Projects:
Project IDFunderFunder ID
UNSPECIFIEDDepartment of Healthhttp://dx.doi.org/10.13039/501100000276
068362/Z/02/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
FS/08/022/24946British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
GO501295Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
UNSPECIFIEDCancer Research UKhttp://dx.doi.org/10.13039/501100000289
MC_U105960384Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
UNSPECIFIEDChief Scientist Officehttp://dx.doi.org/10.13039/501100000589
G0501295Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
PG/06/003British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
PubMed ID: 20739425
Web of Science ID: WOS:000282234100014
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109809
Publisher's version: https://doi.org/10.3945/ajcn.2010.29533

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