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The wisdom of crowds and the repurposing of artesunate as an anticancer drug.

Augustin, Y; Krishna, S; Kumar, D; Pantziarka, P (2015) The wisdom of crowds and the repurposing of artesunate as an anticancer drug. ecancermedicalscience, 9. ed50. ISSN 1754-6605 https://doi.org/10.3332/ecancer.2015.ed50
SGUL Authors: Krishna, Sanjeev

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Abstract

Artesunate, a semi-synthetic and water-soluble artemisinin-derivative used as an anti-malarial agent, has attracted the attention of cancer researchers due to a broad range of anti-cancer activity including anti-angiogenic, immunomodulatory and treatment-sensitisation effects. In addition to pre-clinical evidence in a range of cancers, a recently completed randomised blinded trial in colorectal cancer has provided a positive signal for further clinical investigation. Used perioperatively artesunate appears to reduce the rate of disease recurrence - and the Neo-Art trial, a larger Phase II RCT, is seeking to confirm this positive effect. However, artesunate is a generic medication, and as with other trials of repurposed drugs, the Neo-Art trial does not have commercial sponsorship. In an innovative move, the trial is seeking funds directly from members of the public via a crowd-funding strategy that may have resonance beyond this single trial.

Item Type: Article
Additional Information: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: ecancermedicalscience
ISSN: 1754-6605
Language: eng
Dates:
DateEvent
13 October 2015Published
Publisher License: Creative Commons: Attribution 3.0
PubMed ID: 26557887
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109787
Publisher's version: https://doi.org/10.3332/ecancer.2015.ed50

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