SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Proof of concept study of a novel pacemapping algorithm as a basis to guide ablation of ventricular arrhythmias.

Li, A; Davis, JS; Grimster, A; Wierwille, J; Herold, K; Morgan, D; Behr, ER; Shorofsky, S; Saba, M (2018) Proof of concept study of a novel pacemapping algorithm as a basis to guide ablation of ventricular arrhythmias. Europace, 20 (10). pp. 1647-1656. ISSN 1532-2092 https://doi.org/10.1093/europace/euy024
SGUL Authors: Behr, Elijah Raphael

[img]
Preview
PDF Accepted Version
Available under License ["licenses_description_publisher" not defined].

Download (1MB) | Preview

Abstract

Aims: To determine if a software algorithm can use an individualized distance-morphology difference model, built from three initial pacemaps, to prospectively locate the exit site (ES) of ventricular arrhythmias (VA). Methods and results: Consecutive patients undergoing ablation of VA from a single centre were recruited. During mapping, three initial pacing points were collected in the chamber of interest and the navigation algorithm applied to predict the ES, which was corroborated by conventional mapping techniques. Thirty-two patients underwent ES prediction over 35 procedures. Structural heart disease was present in 16 (7 ischaemic cardiomyopathy, 9 non-ischaemic cardiomyopathy), median ejection fraction 45% [Interquartile range (IQR) 26]. The remainder had normal hearts. The navigation algorithm was applied to 46 VA (24 left ventricle, 11 right ventricular outflow tract, 5 left ventricular outflow tract, 4 right ventricle, 2 epicardial) and successfully located the site of best pacemap match in 45 within a median area of 196.5 mm2 (IQR 161.3, range 46.6-1288.2 mm2). Conclusions: In a diverse population of patients with and without structural heart disease, the ES of VA can be accurately and reliably identified to within a clinically useful target area using a simple software navigation algorithm based on pacemapping.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Europace following peer review. The version of record Anthony Li, Joseph Samuel Davis, Alexander Grimster, Jeremiah Wierwille, Keith Herold, Dennis Morgan, Elijah R Behr, Stephen Shorofsky, Magdi Saba; Proof of concept study of a novel pacemapping algorithm as a basis to guide ablation of ventricular arrhythmias, EP Europace, Volume 20, Issue 10, 1 October 2018, Pages 1647–1656 is available online at: https://doi.org/10.1093/europace/euy024
Keywords: Cardiovascular System & Hematology, 1103 Clinical Sciences
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Europace
ISSN: 1532-2092
Language: eng
Dates:
DateEvent
1 October 2018Published
8 March 2018Published Online
1 February 2018Accepted
Publisher License: Publisher's own licence
PubMed ID: 29528391
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109722
Publisher's version: https://doi.org/10.1093/europace/euy024

Actions (login required)

Edit Item Edit Item