Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

An approach to familial lymphoedema.

Jones, GE; Mansour, S (2017) An approach to familial lymphoedema. Clin Med (Lond), 17 (6). pp. 552-557. ISSN 1473-4893
SGUL Authors: Mansour, Sahar

PDF Published Version
Available under License ["licenses_description_publisher" not defined].

Download (508kB) | Preview
PDF Accepted Version
Available under License ["licenses_description_publisher" not defined].

Download (565kB) | Preview


Lymphoedema is the build-up of lymphatic fluid leading to swelling in the tissues. Most commonly it affects the peripheries. Diagnosis is based on clinical assessment and imaging with lymphoscintigraphy. Treatment is supportive with compression garments, massage, good skin hygiene and prompt use of antibiotics to avoid the complication of cellulitis. Most commonly, lymphoedema occurs as a result of damage to the lymphatic system following surgery, trauma, radiation or infection. However, it can be primary, often associated with a genetic defect that causes disruption to the development of the lymphatic system. Common genetic conditions associated with lymphoedema include Turner syndrome and Noonan syndrome; however, there are numerous others that can be classified based on their clinical presentation and associated features. Herein we discuss how to diagnose and classify the known primary lymphoedema conditions and how best to investigate and manage this group of patients.

Item Type: Article
Additional Information: © Royal College of Physicians 2017. All rights reserved.
Keywords: Chromosomal, hereditary, lymphatic, primary lymphoedema, single gene, General Clinical Medicine, 1103 Clinical Sciences
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Clin Med (Lond)
ISSN: 1473-4893
Language: eng
1 December 2017Published
Publisher License: Publisher's own licence
PubMed ID: 29196357
Web of Science ID: WOS:000417550800012
Go to PubMed abstract
Publisher's version:


Item downloaded times since 04 Apr 2018.

Actions (login required)

Edit Item Edit Item