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Assessment of iron overload with T2* magnetic resonance imaging.

Anderson, LJ (2011) Assessment of iron overload with T2* magnetic resonance imaging. Prog Cardiovasc Dis, 54 (3). pp. 287-294. ISSN 1873-1740 https://doi.org/10.1016/j.pcad.2011.07.004
SGUL Authors: Anderson, Lisa

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Abstract

T2* is a magnetic relaxation property of any tissue and is inversely related to intracellular iron stores. Measurement is simple, quick, and robust and has high reproducibility. The ability to measure ventricular function plus T2* in the heart and liver during the same scan has revolutionized the understanding of iron storage disease and the management of the iron-loaded patient. The early findings using T2* challenged conventional teachings, and both the technique and the findings were initially viewed with scepticism. However, after a decade of work in validating, calibrating, and expanding access to this method, it is now accepted as the method of choice for tissue iron assessment. In the UK, where T2* measurement was first used in the clinical care of patients with thalassemia major, a large and significant fall in mortality has been seen in this patient group.

Item Type: Article
Additional Information: © 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Cardiomyopathies, Humans, Iron, Iron Overload, Magnetic Resonance Imaging, Myocardium, Predictive Value of Tests, Prognosis, Severity of Illness Index, Thalassemia, Myocardium, Humans, Cardiomyopathies, Thalassemia, Iron Overload, Iron, Magnetic Resonance Imaging, Prognosis, Severity of Illness Index, Predictive Value of Tests, Cardiac magnetic resonance T2*, Iron overload cardiomyopathy, Iron chelation therapy, Thalassemia major, Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Cardiovascular System & Cardiology, CARDIAC & CARDIOVASCULAR SYSTEMS, Cardiac magnetic resonance T2*, Iron overload cardiomyopathy, Iron chelation therapy, Thalassemia major, BETA-THALASSEMIA MAJOR, T2-ASTERISK-CARDIOVASCULAR MAGNETIC-RESONANCE, MYOCARDIAL IRON, CARDIAC IRON, IDIOPATHIC HEMOCHROMATOSIS, ORAL DEFERIPRONE, TISSUE IRON, HEART-CELLS, LIVER IRON, IN-VIVO, Cardiovascular System & Hematology, 1102 Cardiovascular Medicine And Haematology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Journal or Publication Title: Prog Cardiovasc Dis
ISSN: 1873-1740
Language: eng
Dates:
DateEvent
November 2011Published
19 October 2011Published Online
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 22014495
Web of Science ID: WOS:000296304300011
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/109543
Publisher's version: https://doi.org/10.1016/j.pcad.2011.07.004

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