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Improved Exercise-Related Skeletal Muscle Oxygen Consumption Following Uptake of Endurance Training Measured Using Near-Infrared Spectroscopy

Jones, S; D'Silva, A; Bhuva, A; Lloyd, G; Manisty, C; Moon, JC; Sharma, S; Hughes, AD (2017) Improved Exercise-Related Skeletal Muscle Oxygen Consumption Following Uptake of Endurance Training Measured Using Near-Infrared Spectroscopy. FRONTIERS IN PHYSIOLOGY, 8. p. 1018. ISSN 1664-042X https://doi.org/10.3389/fphys.2017.01018
SGUL Authors: Sharma, Sanjay

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Abstract

Skeletal muscle metabolic function is known to respond positively to exercise interventions. Developing non-invasive techniques that quantify metabolic adaptations and identifying interventions that impart successful response are ongoing challenges for research. Healthy non-athletic adults (18–35 years old) were enrolled in a study investigating physiological adaptations to a minimum of 16 weeks endurance training prior to undertaking their first marathon. Before beginning training, participants underwent measurements of skeletal muscle oxygen consumption using near-infrared spectroscopy (NIRS) at rest (resting muscleV˙O2) and immediately following a maximal exercise test (post-exercise muscleV˙O2). Exercise-related increase in muscleV˙O2 (ΔmV˙O2) was derived from these measurements and cardio-pulmonary peakV˙O2 measured by analysis of expired gases. All measurements were repeated within 3 weeks of participants completing following the marathon and marathon completion time recorded. MuscleV˙O2 was positively correlated with cardio-pulmonary peakV˙O2 (r = 0.63, p < 0.001). MuscleV˙O2 increased at follow-up (48% increase; p = 0.004) despite no change in cardio-pulmonary peakV˙O2 (0% change; p = 0.97). Faster marathon completion time correlated with higher cardio-pulmonary peakV˙O2 (rpartial = −0.58, p = 0.002) but not muscleV˙O2 (rpartial = 0.16, p = 0.44) after adjustment for age and sex [and adipose tissue thickness (ATT) for muscleV˙O2 measurements]. Skeletal muscle metabolic adaptions occur following training and completion of a first-time marathon; these can be identified non-invasively using NIRS. Although the cardio-pulmonary system is limiting for running performance, skeletal muscle changes can be detected despite minimal improvement in cardio-pulmonary function.

Item Type: Article
Additional Information: © 2017 Jones, D'Silva, Bhuva, Lloyd, Manisty, Moon, Sharma and Hughes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: endurance exercise, oxygen consumption, NIRS, skeletal muscle, (V) over dot O-2 kinetics
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Journal or Publication Title: FRONTIERS IN PHYSIOLOGY
ISSN: 1664-042X
Dates:
DateEvent
12 December 2017Published
24 November 2017Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
FS/15/27/31465British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
UNSPECIFIEDCardiac Risk in the YoungUNSPECIFIED
PG/15/75/31748British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
CS/15/6/31468British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
CS/13/1/30327British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
UNSPECIFIEDNational Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
Web of Science ID: WOS:000417737200001
URI: http://openaccess.sgul.ac.uk/id/eprint/109458
Publisher's version: https://doi.org/10.3389/fphys.2017.01018

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