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A unifying motor control framework for task-specific dystonia.

Sadnicka, A; Kornysheva, K; Rothwell, JC; Edwards, MJ (2018) A unifying motor control framework for task-specific dystonia. Nat Rev Neurol, 14 (2). pp. 116-124. ISSN 1759-4766 https://doi.org/10.1038/nrneurol.2017.146
SGUL Authors: Sadnicka, Anna

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Abstract

Task-specific dystonia is a movement disorder characterized by a painless loss of dexterity specific to a particular motor skill. This disorder is prevalent among writers, musicians, dancers and athletes. No current treatment is predictably effective, and the disorder generally ends the careers of affected individuals. Traditional disease models of dystonia have a number of limitations with regard to task-specific dystonia. We therefore discuss emerging evidence that the disorder has its origins within normal compensatory mechanisms of a healthy motor system in which the representation and reproduction of motor skill are disrupted. We describe how risk factors for task-specific dystonia can be stratified and translated into mechanisms of dysfunctional motor control. The proposed model aims to define new directions for experimental research and stimulate therapeutic advances for this highly disabling disorder.

Item Type: Article
Additional Information: © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Neuroscience (INCCNS)
Journal or Publication Title: Nat Rev Neurol
ISSN: 1759-4766
Language: eng
Dates:
DateEvent
February 2018Published
6 November 2017Published Online
1 October 2017Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
098881/Z/12/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
UNSPECIFIEDNational Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
PubMed ID: 29104291
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109319
Publisher's version: https://doi.org/10.1038/nrneurol.2017.146

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