SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Antimicrobial resistance in UK neonatal units: neonIN infection surveillance network.

Cailes, B; Kortsalioudaki, C; Buttery, J; Pattnayak, S; Greenough, A; Matthes, J; Bedford Russell, A; Kennea, N; Heath, PT; neonIN network (2018) Antimicrobial resistance in UK neonatal units: neonIN infection surveillance network. Arch Dis Child Fetal Neonatal Ed, 103 (5). F474-F478. ISSN 1468-2052 https://doi.org/10.1136/archdischild-2017-313238
SGUL Authors: Heath, Paul Trafford Kennea, Nigel

[img] Microsoft Word (.docx) Accepted Version
Available under License ["licenses_description_publisher" not defined].

Download (36kB)

Abstract

OBJECTIVE: To define the susceptibilities of the common causative pathogens of neonatal sepsis in the UK. DESIGN: Retrospective analysis of the prospectively collected neonIN infection surveillance network data between 2005 and 2014. SETTING: 30 neonatal units in the UK. PATIENTS: Newborns admitted to participating neonatal units who return a positive blood, cerebrospinal fluid or urine culture and are treated with at least 5 days of appropriate antibiotics. RESULTS: 1568 isolates with recorded antimicrobial data were collected including 328 early-onset sepsis (EOS) isolates and 1240 late-onset sepsis (LOS) isolates. The majority of EOS pathogens (>92%) were susceptible to the four empirical commonly used antimicrobial combinations (eg, 93% for benzylpenicillin/gentamicin), while LOS pathogens demonstrated higher levels of resistance (eg, 89% for flucloxacillin/gentamicin). Among infants<1500 g and <32 weeks gestation, an amoxicillin/gentamicin combination demonstrated a trend towards improved coverage of EOS isolates than benzylpenicillin/gentamicin (93% vs 86%, p=0.211). CONCLUSIONS: This analysis provides insights into the patterns of antimicrobial resistance among UK neonatal pathogens. These data will inform areas of future research and can be used to update national evidence-based guidelines on antimicrobial usage.

Item Type: Article
Additional Information: This article has been accepted for publication in Archives of Disease in Childhood. Fetal and Neonatal edition following peer review. The definitive copyedited, typeset version Cailes B, Kortsalioudaki C, Buttery J on behalf of the neonIN network, et al Antimicrobial resistance in UK neonatal units: neonIN infection surveillance network Archives of Disease in Childhood - Fetal and Neonatal Edition 2018;103:F474-F478 is available online at: http://dx.doi.org/10.1136/archdischild-2017-313238
Keywords: epidemiology, infectious diseases, intensive care, neonatology, epidemiology, infectious diseases, intensive care, neonatology, Pediatrics, 1114 Paediatrics And Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: Arch Dis Child Fetal Neonatal Ed
ISSN: 1468-2052
Language: eng
Dates:
DateEvent
September 2018Published
26 October 2017Published Online
26 September 2017Accepted
Publisher License: Publisher's own licence
PubMed ID: 29074716
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109275
Publisher's version: https://doi.org/10.1136/archdischild-2017-313238

Actions (login required)

Edit Item Edit Item