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SIgA, TGF-beta 1, IL-10, and TNF alpha in Colostrum Are Associated with Infant Group B Streptococcus Colonization

Le Doare, K; Bellis, K; Faal, A; Birt, J; Munblit, D; Humphries, H; Taylor, S; Warburton, F; Heath, PT; Kampmann, B; et al. Le Doare, K; Bellis, K; Faal, A; Birt, J; Munblit, D; Humphries, H; Taylor, S; Warburton, F; Heath, PT; Kampmann, B; Gorringe, A (2017) SIgA, TGF-beta 1, IL-10, and TNF alpha in Colostrum Are Associated with Infant Group B Streptococcus Colonization. FRONTIERS IN IMMUNOLOGY, 8. p. 1269. ISSN 1664-3224 https://doi.org/10.3389/fimmu.2017.01269
SGUL Authors: Heath, Paul Trafford

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Abstract

Background: Group B Streptococcus (GBS) is a major cause of mortality and morbidity in infants and is associated with transmission from a colonized mother at birth and via infected breastmilk. Although maternal/infant colonization with GBS is common, the majority of infants exposed to GBS remain unaffected. The association between breastmilk immune factors and infant colonization and disease prevention has not been elucidated. Objectives: We have investigated the association between SIgA and cytokines in breastmilk and infant GBS colonization and clearance. Methods: Mother/infant GBS colonization was determined in a prospective cohort of 750 Gambian mother/infant pairs followed to day 89 of life. Anti-GBS secretory IgA bound to the surface of whole bacteria was assessed by flow cytometry and a panel of 12 cytokines quantified by mesoscale discovery in colostrum, breastmilk and serum. Results: Compared with infants receiving low anti-GBS SIgA in colostrum, infants receiving high anti-GBS SIgA were at decreased risk of GBS colonization for serotypes III and V. Infants colonized at day 6 were twice as likely to receive colostrum with high TGF-β1, TNFα, IL10, and IL-6 compared to uncolonized infants. Infants receiving high colostral TGF-β1, TNFα, and IL-6 had two-fold enhanced GBS clearance between birth and day 89. Conclusion: Our results suggest that the infant GBS colonization risk diminishes with increasing anti-GBS SIgA antibody in breastmilk and that key maternally derived cytokines might contribute to protection against infant colonization. These findings might be leveraged to develop interventions including maternal vaccination that may reduce infant GBS colonization.

Item Type: Article
Additional Information: © 2017 Le Doare, Bellis, Faal, Birt, Munblit, Humphries, Taylor, Warburton, Heath, Kampmann and Gorringe. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: breast milk, antibody, cytokines, neonatal immunity, microbiome, Group B Streptococcus
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: FRONTIERS IN IMMUNOLOGY
ISSN: 1664-3224
Dates:
DateEvent
20 October 2017Published
25 September 2017Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
WT2015Wellcome Trusthttp://dx.doi.org/10.13039/100004440
12250Thrasher Research Fundhttp://dx.doi.org/10.13039/100005627
MC_UP_A900/1122Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MC_UP_A900/115Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
Web of Science ID: WOS:000413288100001
URI: http://openaccess.sgul.ac.uk/id/eprint/109265
Publisher's version: https://doi.org/10.3389/fimmu.2017.01269

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