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Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Demenais, F; Margaritte-Jeannin, P; Barnes, KC; Cookson, WOC; Altmüller, J; Ang, W; Barr, RG; Beaty, TH; Becker, AB; Beilby, J; et al. Demenais, F; Margaritte-Jeannin, P; Barnes, KC; Cookson, WOC; Altmüller, J; Ang, W; Barr, RG; Beaty, TH; Becker, AB; Beilby, J; Bisgaard, H; Bjornsdottir, US; Bleecker, E; Bønnelykke, K; Boomsma, DI; Bouzigon, E; Brightling, CE; Brossard, M; Brusselle, GG; Burchard, E; Burkart, KM; Bush, A; Chan-Yeung, M; Chung, KF; Couto Alves, A; Curtin, JA; Custovic, A; Daley, D; de Jongste, JC; Del-Rio-Navarro, BE; Donohue, KM; Duijts, L; Eng, C; Eriksson, JG; Farrall, M; Fedorova, Y; Feenstra, B; Ferreira, MA; Australian Asthma Genetics Consortium (AAGC) collaborators; Freidin, MB; Gajdos, Z; Gauderman, J; Gehring, U; Geller, F; Genuneit, J; Gharib, SA; Gilliland, F; Granell, R; Graves, PE; Gudbjartsson, DF; Haahtela, T; Heckbert, SR; Heederik, D; Heinrich, J; Heliövaara, M; Henderson, J; Himes, BE; Hirose, H; Hirschhorn, JN; Hofman, A; Holt, P; Hottenga, J; Hudson, TJ; Hui, J; Imboden, M; Ivanov, V; Jaddoe, VWV; James, A; Janson, C; Jarvelin, M-R; Jarvis, D; Jones, G; Jonsdottir, I; Jousilahti, P; Kabesch, M; Kähönen, M; Kantor, DB; Karunas, AS; Khusnutdinova, E; Koppelman, GH; Kozyrskyj, AL; Kreiner, E; Kubo, M; Kumar, R; Kumar, A; Kuokkanen, M; Lahousse, L; Laitinen, T; Laprise, C; Lathrop, M; Lau, S; Lee, Y-A; Lehtimäki, T; Letort, S; Levin, AM; Li, G; Liang, L; Loehr, LR; London, SJ; Loth, DW; Manichaikul, A; Marenholz, I; Martinez, FJ; Matheson, MC; Mathias, RA; Matsumoto, K; Mbarek, H; McArdle, WL; Melbye, M; Melén, E; Meyers, D; Michel, S; Mohamdi, H; Musk, AW; Myers, RA; Nieuwenhuis, MAE; Noguchi, E; O'Connor, GT; Ogorodova, LM; Palmer, CD; Palotie, A; Park, JE; Pennell, CE; Pershagen, G; Polonikov, A; Postma, DS; Probst-Hensch, N; Puzyrev, VP; Raby, BA; Raitakari, OT; Ramasamy, A; Rich, SS; Robertson, CF; Romieu, I; Salam, MT; Salomaa, V; Schlünssen, V; Scott, R; Selivanova, PA; Sigsgaard, T; Simpson, A; Siroux, V; Smith, LJ; Solodilova, M; Standl, M; Stefansson, K; Strachan, DP; Stricker, BH; Takahashi, A; Thompson, PJ; Thorleifsson, G; Thorsteinsdottir, U; Tiesler, CMT; Torgerson, DG; Tsunoda, T; Uitterlinden, AG; van der Valk, RJP; Vaysse, A; Vedantam, S; von Berg, A; von Mutius, E; Vonk, JM; Waage, J; Wareham, NJ; Weiss, ST; White, WB; Wickman, M; Widén, E; Willemsen, G; Williams, LK; Wouters, IM; Yang, JJ; Zhao, JH; Moffatt, MF; Ober, C; Nicolae, DL (2018) Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet, 50 (1). pp. 42-53. ISSN 1546-1718 https://doi.org/10.1038/s41588-017-0014-7
SGUL Authors: Strachan, David Peter

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Abstract

We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.

Item Type: Article
Additional Information: This is a post-peer-review, pre-copyedit version of an article published in Nature Genetics. The final authenticated version is available online at: http://dx.doi.org/10.1038/s41588-017-0014-7
Keywords: Developmental Biology, 11 Medical And Health Sciences, 06 Biological Sciences
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Nat Genet
ISSN: 1546-1718
Language: eng
Dates:
DateEvent
January 2018Published
21 December 2017Published Online
4 November 2017Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
G0401540Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
U01 HL130114NHLBI NIH HHSUNSPECIFIED
R01 HL077612NHLBI NIH HHSUNSPECIFIED
MR/K002449/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
G0601361Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MC_UU_12015/1Medical Research CouncilUNSPECIFIED
RC2 HL101651NHLBI NIH HHSUNSPECIFIED
648916European Research Councilhttp://dx.doi.org/10.13039/501100000781
G0902125Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
G9815508Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
G0500539Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
G0600705Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
G1002319Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
UNSPECIFIEDCancer Research UKhttp://dx.doi.org/10.13039/501100000289
UNSPECIFIEDBritish Heart Foundationhttp://dx.doi.org/10.13039/501100000274
068545/Z/02Wellcome Trusthttp://dx.doi.org/10.13039/100004440
G0000934Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
076113/B/04/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
079895Wellcome Trusthttp://dx.doi.org/10.13039/100004440
WT084703MAWellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 29273806
Web of Science ID: WOS:000423157400008
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109029
Publisher's version: https://doi.org/10.1038/s41588-017-0014-7

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