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Safety of intracoronary provocative testing for the diagnosis of coronary artery spasm.

Ciliberti, G; Seshasai, SRK; Ambrosio, G; Kaski, JC (2017) Safety of intracoronary provocative testing for the diagnosis of coronary artery spasm. Int J Cardiol, 244. pp. 77-83. ISSN 1874-1754 https://doi.org/10.1016/j.ijcard.2017.05.109
SGUL Authors: Kaski, Juan Carlos

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Abstract

AIMS: Systematic review of literature to evaluate safety of intracoronary (i.c.) pharmacologic testing with acetylcholine (ACh), or ergonovine (ERGO), to induce coronary artery spasm. METHODS AND RESULTS: Review of all relevant publications using MEDLINE and EMBASE databases yielded 10 publications, totalling 9,444 patients. Prevalence of provoked spasm varied from 2.3% to 54.7% of patients tested in the selected studies. The wide variability in prevalence was due to heterogeneity of study populations and provocation protocols. No deaths were reported. Overall occurrence of major (0.8%) and minor (4.7%) complications for i.c. pharmacologic testing was low. Compared to ERGO, ACh showed significantly higher rate of major (1.09% vs 0.15%; p<0.001) and minor complications (5.87% vs 2.36%; p<0.001). CONCLUSION: Provocative testing with i.c. ACh or ERGO are safe and can facilitate the diagnosis of inducible coronary artery spasm during diagnostic coronary angiography. These tests should be part of the routine armamentarium of interventional cardiologists.

Item Type: Article
Additional Information: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Acetylcholine, Coronary artery spasm, Ergonovine, Microvascular constriction, Coronary artery spasm, Acetylcholine, Ergonovine, Microvascular constriction, Acetylcholine, Coronary artery spasm, Ergonovine, Microvascular constriction, Cardiovascular System & Hematology, 1102 Cardiovascular Medicine And Haematology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Int J Cardiol
ISSN: 1874-1754
Language: eng
Dates:
DateEvent
1 October 2017Published
1 June 2017Published Online
31 May 2017Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 28622945
Web of Science ID: WOS:000406943600013
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/108982
Publisher's version: https://doi.org/10.1016/j.ijcard.2017.05.109

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