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A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.

Kumar, V; Yadav, AK; Lal, A; Kumar, V; Singhal, M; Billot, L; Gupta, KL; Banerjee, D; Jha, V (2017) A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD. J Am Soc Nephrol, 28 (10). pp. 3100-3108. ISSN 1533-3450 https://doi.org/10.1681/ASN.2017010003
SGUL Authors: Banerjee, Debasish

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Abstract

Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovascular disease risk in CKD. In this randomized, double-blind, placebo-controlled trial, we investigated the effect of cholecalciferol supplementation on vascular function in 120 patients of either sex, aged 18-70 years, with nondiabetic CKD stage 3-4 and vitamin D deficiency (serum 25-hydroxyvitamin D ≤20 ng/ml). We randomized patients using a 1:1 ratio to receive either two directly observed oral doses of cholecalciferol (300,000 IU) or matching placebo at baseline and 8 weeks. The primary outcome was change in endothelium-dependent brachial artery flow-mediated dilation at 16 weeks. Secondary outcome measures included changes in pulse wave velocity and circulating biomarkers. Cholecalciferol supplementation significantly increased endothelium-dependent brachial artery flow-mediated dilation at 16 weeks, whereas placebo did not (between-group difference in mean change: 5.49%; 95% confidence interval, 4.34% to 6.64%; P<0.001). Intervention also led to significant favorable changes in pulse wave velocity and circulating IL-6 levels. Thus, in nondiabetic patients with stage 3-4 CKD and vitamin D deficiency, vitamin D supplementation may improve vascular function. This study is registered with the Clinical Trials Registry of India (no.: CTRI/2013/05/003648).

Item Type: Article
Additional Information: Copyright © 2017 by the American Society of Nephrology
Keywords: Vitamin D, cardiovascular disease, chronic kidney disease, Urology & Nephrology, 1103 Clinical Sciences
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Journal or Publication Title: J Am Soc Nephrol
ISSN: 1533-3450
Language: eng
Dates:
DateEvent
October 2017Published
30 June 2017Published Online
3 May 2017Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
BT/PR3150/MED/30/640/2011Department of Biotechnology, Government of IndiaUNSPECIFIED
PubMed ID: 28667080
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/108938
Publisher's version: https://doi.org/10.1681/ASN.2017010003

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